Technology Process of (S)-N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-yl)-2-chlorobenzenesulfonamide
There total 8 articles about (S)-N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-yl)-2-chlorobenzenesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine;
In
tetrahydrofuran;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl / 0.5 h / 150 °C / Irradiation with microwave
2: lithium borohydride / tetrahydrofuran; methanol / 20 °C / Inert atmosphere of nitrogen
3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C
4: hydrogenchloride; hydrogen / 20% palladium hydroxide-activated charcoal / ethanol; water / 1 h / 1500.15 Torr
5: triethylamine / tetrahydrofuran / 20 °C
With
hydrogenchloride; lithium borohydride; hydrogen; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl;
20% palladium hydroxide-activated charcoal;
In
tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / water; ethyl acetate / 20 °C / Cooling with ice bath
2: 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl / 0.5 h / 150 °C / Irradiation with microwave
3: lithium borohydride / tetrahydrofuran; methanol / 20 °C / Inert atmosphere of nitrogen
4: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C
5: hydrogenchloride; hydrogen / 20% palladium hydroxide-activated charcoal / ethanol; water / 1 h / 1500.15 Torr
6: triethylamine / tetrahydrofuran / 20 °C
With
hydrogenchloride; lithium borohydride; hydrogen; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl;
20% palladium hydroxide-activated charcoal;
In
tetrahydrofuran; methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;