2-[(2',6'-dimethoxy-biphenyl-2-yl)-(2-methoxy-phenyl)-phosphanyl]-toluenesulfonic acid

Base Information

• Chemical Name: 2-[(2',6'-dimethoxy-biphenyl-2-yl)-(2-methoxy-phenyl)-phosphanyl]-toluenesulfonic acid
• CAS No.: 1049683-69-3
• Molecular Formula: C₂₈H₂₇O₆PS
• Molecular Weight: 522.559
• Mol file: 1049683-69-3.mol

Synonyms:2-[(2',6'-dimethoxy-biphenyl-2-yl)-(2-methoxy-phenyl)-phosphanyl]-toluenesulfonic acid

Chemical Property of 2-[(2',6'-dimethoxy-biphenyl-2-yl)-(2-methoxy-phenyl)-phosphanyl]-toluenesulfonic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-[(2',6'-dimethoxy-biphenyl-2-yl)-(2-methoxy-phenyl)-phosphanyl]-toluenesulfonic acid

There total 1 articles about 2-[(2',6'-dimethoxy-biphenyl-2-yl)-(2-methoxy-phenyl)-phosphanyl]-toluenesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromoanisole (578-57-4) + toluene-4-sulfonic acid (104-15-4) + 2'-bromo-2,6-dimethoxybiphenyl (755017-61-9) → 2-[(2',6'-dimethoxy-biphenyl-2-yl)-(2-methoxy-phenyl)-phosphanyl]-toluenesulfonic acid (1049683-69-3)

Guidance literature:

toluene-4-sulfonic acid; With n-butyllithium; In tetrahydrofuran; at -78 - 0 ℃;

With phosphorus trichloride; In tetrahydrofuran; at -78 ℃; for 0.75h;

2-bromoanisole; 2'-bromo-2,6-dimethoxybiphenyl; With hydrogenchloride; n-butyllithium; water; magnesium; more than 3 stages;

Reference yield: 51.0%

2,6-dimethylpyridine (108-48-5) + dibromo(cyclo-octa-1,5-diene)palladium(II) (12145-47-0) + 2-[(2',6'-dimethoxy-biphenyl-2-yl)-(2-methoxy-phenyl)-phosphanyl]-toluenesulfonic acid (1049683-69-3) → C35H35BrNO6PPdS

Guidance literature:

In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.201611198

Reference yield:

2-[(2',6'-dimethoxy-biphenyl-2-yl)-(2-methoxy-phenyl)-phosphanyl]-toluenesulfonic acid (1049683-69-3) → {2-[(2-methoxyphenyl)(2',6'-dimethoxylbiphenyl)phosphino]toluene-sulfonic acid}palladium dimer

Guidance literature:

In tetrahydrofuran; for 1h;

upstream raw materials:

2-bromoanisole

toluene-4-sulfonic acid

2'-bromo-2,6-dimethoxybiphenyl

Refernces