3-CHLOROPROPYLMETHYLSULFANE

Base Information

• Chemical Name: 3-CHLOROPROPYLMETHYLSULFANE
• CAS No.: 13012-59-4
• Molecular Formula: C4H9 Cl S
• Molecular Weight: 124.63
• Hs Code.: 2930909090
• Mol file: 13012-59-4.mol

Synonyms:Sulfide,3-chloropropyl methyl (7CI,8CI); 1-(Methylthio)-3-chloropropane;1-Chloro-3-methylthiopropane; 3-Chloropropyl methyl sulfide

Chemical Property of 3-CHLOROPROPYLMETHYLSULFANE

Chemical Property:

• Vapor Pressure: 2.096mmHg at 25°C
• Refractive Index: 1.47
• Boiling Point: 168.9°C at 760 mmHg
• Flash Point: 62.298°C
• PSA: 25.30000
• Density: 1.039g/cm³
• LogP: 1.97830

Purity/Quality:

98%min ^*data from raw suppliers

1-chloro-3-(methylsulfanyl)propane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLOROPROPYLMETHYLSULFANE

There total 8 articles about 3-CHLOROPROPYLMETHYLSULFANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-(methylthio)-1-propanol (505-10-2) → 3-methylthiopropyl chloride (13012-59-4)

Guidance literature:

With thionyl chloride; In chloroform; for 4h; Wavelength; Reflux;

Reference yield: 53.0%

methylthiol (74-93-1) + 1,3-Dichloropropane (142-28-9) → 3-methylthiopropyl chloride (13012-59-4) + 1,3-bis(methylthio)propane (24949-35-7)

Guidance literature:

With sodium ethanolate; In ethanol; for 10h; Yields of byproduct given; Ambient temperature;

DOI:10.1055/s-1987-28097

Reference yield: 53.0%

1,3-Diiodopropane (627-31-6) + 1,3-Dichloropropane (142-28-9) → 3-methylthiopropyl chloride (13012-59-4) + 1,3-bis(methylthio)propane (24949-35-7)

Guidance literature:

With sodium ethanolate; In ethanol; for 10h; Yield given; Ambient temperature;

DOI:10.1055/s-1987-28097

upstream raw materials:

3-(methylthio)-1-propanol

1.3-chlorobromopropane

sodium thiomethoxide

methylthiol

Downstream raw materials:

2-<2-(Methylthio)propyl>-1H-isoindole-1,3(2H)-dione

2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-5-[3-(methylsulfanyl)propoxy]-N-(pyridin-4-yl)-pyrimidin-4-amine

p-Cyano-N-(3-methylthio)propylaniline

1-chloro-3-(methanesulfonyl)propane

Refernces

• 1、 Mavratzotis,Dourtoglou,Lorin,Rollin. "Glucosinolate chemistry. First synthesis of glucosinolates bearing an external thio-function". . p. 5699 - 5700. Retrieved 1996.
• 2、 Terada, Yuko,Masuda, Hideki,Watanabe, Tatsuo. "Structure-Activity Relationship Study on Isothiocyanates: Comparison of TRPA1-Activating Ability between Allyl Isothiocyanate and Specific Flavor Components of Wasabi, Horseradish, and White Mustard". . p. 1937 - 1941. Retrieved 2015.
• 3、 -. "Method for preparing 3-methylthio propylamine". Paragraph 0006; 0021; 0025; 0029; 0033. . Retrieved 2018/03/24.