4-Hydroxy-4'-methoxybiphenyl

Base Information

• Chemical Name: 4-Hydroxy-4'-methoxybiphenyl
• CAS No.: 16881-71-3
• Molecular Formula: C13H12O2
• Molecular Weight: 200.237
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID40452569
• Nikkaji Number: J315.144A
• Wikidata: Q82273284
• ChEMBL ID: CHEMBL258552
• Mol file: 16881-71-3.mol

Synonyms:4-Hydroxy-4'-methoxybiphenyl;16881-71-3;4-(4-methoxyphenyl)phenol;4'-methoxy-[1,1'-Biphenyl]-4-ol;4'-Methoxybiphenyl-4-ol;4'-Methoxy[1,1'-biphenyl]-4-ol;4-methoxy-4'-hydroxybiphenyl;CHEMBL258552;4-HYDROXY-4/'-METHOXYBIPHENYL;[1,1'-Biphenyl]-4-ol, 4'-methoxy-;[1,1'-Biphenyl]-4-ol,4'-methoxy-;4-p-Methoxyphenylphenol;4'-methoxy-biphenyl-4-ol;4-methoxy-4'hydroxybiphenyl;4'-methoxy-4-hydroxybiphenyl;4-Hydroxy-4'-methoxydiphenyl;SCHEMBL1341494;DTXSID40452569;CORJIEYQXMZUIW-UHFFFAOYSA-N;4'-methoxy-1,1'-biphenyl-4-ol;BDBM50376220;MFCD00191514;4-hydroxy-4'-methoxy-1,1'-biphenyl;AKOS002679516;AS-61356;BP-10220;BB 0223352;CS-0206068;FT-0657650;H0819;T71905;A811019

Chemical Property of 4-Hydroxy-4'-methoxybiphenyl

Chemical Property:

• Melting Point: 181 °C
• Boiling Point: 344.566 °C at 760 mmHg
• Flash Point: 195.285 °C
• PSA: 29.46000
• Density: 1.13 g/cm³
• LogP: 3.06780
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: almost transparency in Methanol
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 200.083729621
• Heavy Atom Count: 15
• Complexity: 177

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Hydroxy-4''-methoxybiphenyl ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=CC=C(C=C2)O

Technology Process of 4-Hydroxy-4'-methoxybiphenyl

There total 62 articles about 4-Hydroxy-4'-methoxybiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-Iodophenol (540-38-5) + 4-methoxyphenylboronic acid (5720-07-0) → 4'-methoxy-1,1'-biphenyl-4-ol (16881-71-3)

Guidance literature:

With potassium carbonate; 10percent Pd/C; In water; at 20 ℃; for 12h;

DOI:10.1021/jo016342k

Reference yield: 97.0%

4-bromo-phenol (106-41-2) + 4-methoxyphenylboronic acid (5720-07-0) → 4'-methoxy-1,1'-biphenyl-4-ol (16881-71-3)

Guidance literature:

With caesium carbonate; In propan-1-ol; water; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00042

Reference yield: 97.0%

1-bromo-4-methoxy-benzene (104-92-7) + (p-hydroxyphenyl)boronic acid (71597-85-8) → 4'-methoxy-1,1'-biphenyl-4-ol (16881-71-3)

Guidance literature:

With sodium carbonate; In ethanol; water; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.1039/c5ra10585d

upstream raw materials:

4,4'-Dihydroxybiphenyl

dimethyl sulfate

4-methoxy-4-(4-methoxyphenyl)-2,5-cyclohexadienone

N-(phenoxy)-4-methylbenzenesulfonamide

Downstream raw materials:

4'-methoxybiphenyl-4-yl 4-<4-(allyloxy)phenyl>benzoate

(R,S)-4-methoxybiphenyl 4-(3-methyl-2-oxa-4-pentenyl)benzoate

(R)-4-methoxybiphenyl 4-(3-butyl-2-oxa-4-pentenyl)benzoate

(R)-4-methoxybiphenyl 4-(3-cyclohexyl-2-oxa-4-pentenyl)benzoate

Refernces

• 1、 Song, Shuang,Rudick, Jonathan G.. "Efficient Syntheses of Star-Branched, Multifunctional Mesogens". . p. 3244 - 3247. Retrieved 2015.
• 2、 Hassine, Ayoub,Sebti, Sa?d,Solhy, Abderrahim,Zahouily, Mohamed,Len, Christophe,Hedhili, Mohamed Nejib,Fihri, Aziz. "Palladium supported on natural phosphate: Catalyst for Suzuki coupling reactions in water". . p. 13 - 18. Retrieved 2013.
• 3、 Tao, Sheng,Guo, Cheng,Liu, Ning,Dai, Bin. "Counteranion-Controlled Ag2O-Mediated Benzimidazolium Ring Opening and Its Application in the Synthesis of Palladium Pincer-Type Complexes". . p. 4432 - 4442. Retrieved 2017.
• 4、 Liu, Caiping,Han, Jingxuan,Marcelina, Olivia,Nugrahaningrum, Dyah Ari,Huang, Song,Zou, Meijuan,Wang, Guixue,Miyagishi, Makoto,He, Yun,Wu, Shourong,Kasim, Vivi. "Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia". supporting information. p. 135 - 162. Retrieved 2022/01/14.
• 5、 Li, Tang,Pang, Wan,Wang, Jie,Zhang, Xiaoli,Zhao, Zesheng. "Pd Nanoparticles Embedded Into MOF-808: Synthesis, Structural Characteristics, and Catalyst Properties for the Suzuki–Miyaura Coupling Reaction". . . Retrieved 2021/07/31.