(2S)-2-(methylamino)hexanoic acid

Base Information

• Chemical Name: (2S)-2-(methylamino)hexanoic acid
• CAS No.: 17343-27-0
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 145.202
• Hs Code.: 2922499990
• DSSTox Substance ID: DTXSID10426636
• Nikkaji Number: J943.979J
• Wikidata: Q76393669
• Mol file: 17343-27-0.mol

Synonyms:17343-27-0;H-MeNle-OH;N-methyl-L-Norleucine;(2S)-2-(methylamino)hexanoic acid;L-Norleucine, N-methyl-;N-Me-L-norleucine HCl;(S)-2-(Methylamino)hexanoic acid;(2S)-2-(methylazaniumyl)hexanoate;n-methylnorleucine;n-methyl norleucine;L-Norleucine,N-methyl-;SCHEMBL201058;DTXSID10426636;FPDYKABXINADKS-LURJTMIESA-N;AM9198;AKOS006276572;N-Alpha-Methyl-L-2-amino-caproic acid;BS-21721;CS-0210729

Chemical Property of (2S)-2-(methylamino)hexanoic acid

Chemical Property:

• PSA: 49.33000
• LogP: 1.24010
• Storage Temp.: -15°C
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 145.110278721
• Heavy Atom Count: 10
• Complexity: 104

Purity/Quality:

98%Min ^*data from raw suppliers

N-Me-L-norleucine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCC(C(=O)O)NC
• Isomeric SMILES: CCCC[C@@H](C(=O)O)NC
• Uses: N-Me-L-norleucine HCl

Technology Process of (2S)-2-(methylamino)hexanoic acid

There total 3 articles about (2S)-2-(methylamino)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Benzyl-N-methyl-L-norleucin (17345-52-7) → N-methyl-L-NleOH (17343-27-0)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal;

DOI:10.1039/j39680000726

Reference yield:

L-Norleucine (327-57-1) → N-methyl-L-NleOH (17343-27-0)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) NaOH, (ii) aq. NaBH₄

2: aq. HCO₂H

3: H₂, AcOH / Pd-C

With formic acid; hydrogen; acetic acid; palladium on activated charcoal;

DOI:10.1039/j39680000726

Reference yield:

N-Benzyl-L-norleucin (17345-51-6) → N-methyl-L-NleOH (17343-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCO₂H

2: H₂, AcOH / Pd-C

With formic acid; hydrogen; acetic acid; palladium on activated charcoal;

DOI:10.1039/j39680000726

upstream raw materials:

N-Benzyl-N-methyl-L-norleucin

L-Norleucine

N-Benzyl-L-norleucin

Downstream raw materials:

N-BOC-N-methylnorleucine

Refernces