4-NITROPHENYL TRIFLUOROMETHANESULFONATE

Base Information

• Chemical Name: 4-NITROPHENYL TRIFLUOROMETHANESULFONATE
• CAS No.: 17763-80-3
• Molecular Formula: C7H4 F3 N O5 S
• Molecular Weight: 271.174
• Hs Code.: 29089990
• Mol file: 17763-80-3.mol

Synonyms:Methanesulfonicacid, trifluoro-, 4-nitrophenyl ester (9CI); Methanesulfonic acid, trifluoro-,p-nitrophenyl ester (8CI); 4-Nitrophenyl triflate; 4-Nitrophenyltrifluoromethanesulfonate; p-Nitrophenyl triflate

Chemical Property of 4-NITROPHENYL TRIFLUOROMETHANESULFONATE

Chemical Property:

• Vapor Pressure: 0.000301mmHg at 25°C
• Melting Point: 52-55 °C(lit.)
• Refractive Index: 1.506
• Boiling Point: 331.4°Cat760mmHg
• Flash Point: 154.2°C
• PSA: 97.57000
• Density: 1.666g/cm³
• LogP: 3.42720
• Storage Temp.: Keep Cold
• Sensitive.: Moisture Sensitive
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Nitrophenyl Trifluoromethanesulfonate >99.0%(GC) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Nitrophenyl trifluoromethanesulfonate (4-nitrophenyltriflate) may be used in the following studies:As a triflating agent in the synthesis of aryl triflates.As a reagent in the synthesis of aryl nonaflate.As a reagent for palladium catalyzed coupling reactions with different substrates.

Technology Process of 4-NITROPHENYL TRIFLUOROMETHANESULFONATE

There total 17 articles about 4-NITROPHENYL TRIFLUOROMETHANESULFONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

polymer, 1.6 mmol/g NTf2 units; monomer(s): styrene; 1,4-bis(4-vinylphenoxy)butane; N-(4-vinylphenyl)trifluoromethanesulfonimide + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → para-nitrophenyl triflate (17763-80-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.tet.2004.10.108

Reference yield: 98.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + trifluoromethylsulfonic anhydride (358-23-6) → para-nitrophenyl triflate (17763-80-3)

Guidance literature:

With dmap; In dichloromethane;

DOI:10.1016/S0040-4020(01)89138-9

Reference yield: 84.0%

trifluorormethanesulfonic acid (1493-13-6) + 4-nitrobenzenediazonium tetrafluoroborate (456-27-9) → para-nitrophenyl triflate (17763-80-3)

Guidance literature:

at 100 ℃; for 1h;

upstream raw materials:

Phenyl triflate

4-nitro-phenol

trifluoromethylsulfonic anhydride

trifluorormethanesulfonic acid

Downstream raw materials:

1-(4-nitro-phenyl)-pyrrolidine

1-(4-nitrophenyl)piperidine

1-morpholino-4-nitrobenzene

4-octylaniline

Refernces

• 1、 Pospech, Jola,Taeufer, Tobias. "Palladium-Catalyzed Synthesis of N, N-Dimethylanilines via Buchwald-Hartwig Amination of (Hetero)aryl Triflates". . p. 7097 - 7111. Retrieved 2020/06/27.
• 2、 Zhou, Hai-Shan,Hu, Lv-Bin,Zhang, Han,Shan, Wen-Xin,Wang, Yan,Li, Xue,Liu, Tian,Zhao, Jing,You, Qi-Dong,Jiang, Zheng-Yu. "Design, Synthesis, and Structure-Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors". supporting information. p. 11149 - 11168. Retrieved 2020/11/09.