Technology Process of 5-(3-chlorophenyl)-3-chloro-2-cyanopyridine
There total 5 articles about 5-(3-chlorophenyl)-3-chloro-2-cyanopyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate;
In
water; N,N-dimethyl-formamide;
at 45 ℃;
for 4h;
Inert atmosphere;
Large scale;
DOI:10.1021/acs.oprd.1c00004
- Guidance literature:
-
With
potassium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
water; N,N-dimethyl-formamide;
at 50 ℃;
for 25.5h;
Product distribution / selectivity;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium fluoride; tetramethlyammonium chloride / 1-methyl-pyrrolidin-2-one / 4 h / 150 °C / Inert atmosphere
2: water / 4 h / 60 °C / Inert atmosphere
3: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 25 h / 50 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; tetramethlyammonium chloride; potassium carbonate;
In
1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide;
