ethyl 4-nitrophenyl malonate

Base Information

• Chemical Name: ethyl 4-nitrophenyl malonate
• CAS No.: 24161-55-5
• Molecular Formula: C₁₁H₁₁NO₆
• Molecular Weight: 253.211
• Mol file: 24161-55-5.mol

Synonyms:ethyl 4-nitrophenyl malonate

Chemical Property of ethyl 4-nitrophenyl malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-nitrophenyl malonate

There total 3 articles about ethyl 4-nitrophenyl malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + hydrogen ethyl malonate (1071-46-1) → ethyl 4-nitrophenyl malonate (24161-55-5)

Guidance literature:

With dicyclohexyl-carbodiimide; In acetonitrile; at 25 ℃; for 0.25h;

DOI:10.1039/b312559a

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + ethyl chlorocarbonylacetate (36239-09-5) → ethyl 4-nitrophenyl malonate (24161-55-5)

Guidance literature:

Multistep reaction; (i) NaOMe, MeOH, (ii) /BRN= 636215/, Et₂O;

DOI:10.1021/ja01039a029

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + ethyl potassium malonate (6148-64-7) → ethyl 4-nitrophenyl malonate (24161-55-5)

Guidance literature:

With dicyclohexyl-carbodiimide; Ambient temperature;

DOI:10.1139/v86-190

upstream raw materials:

4-nitro-phenol

ethyl chlorocarbonylacetate

ethyl potassium malonate

hydrogen ethyl malonate

Downstream raw materials:

4-nitro-phenol

ethanol

malonic acid

Refernces

• 1、 Isaacs, Neil S.,Najem, Tariq S.. "Activation volumes for ester hydrolysis via elimination-addition". . p. 1140 - 1144. Retrieved 2007/10/02.