methyl bromo(2,4-difluorophenyl)acetate

Base Information

• Chemical Name: methyl bromo(2,4-difluorophenyl)acetate
• CAS No.: 1266680-51-6
• Molecular Formula: C₉H₇BrF₂O₂
• Molecular Weight: 265.054
• Mol file: 1266680-51-6.mol

Synonyms:methyl bromo(2,4-difluorophenyl)acetate

Chemical Property of methyl bromo(2,4-difluorophenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl bromo(2,4-difluorophenyl)acetate

There total 4 articles about methyl bromo(2,4-difluorophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 2-(2,4-difluorophenyl)acetate (95299-17-5) → methyl bromo(2,4-difluorophenyl)acetate (1266680-51-6)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; at 20 ℃; for 16h; Reflux;

Reference yield: 87.0%

methyl 2-(2,4-difluorophenyl)-2-hydroxyacetate → methyl bromo(2,4-difluorophenyl)acetate (1266680-51-6)

Guidance literature:

With phosphorus tribromide; In chloroform; at 20 ℃; for 96h;

DOI:10.1016/j.bmcl.2018.01.059

Reference yield:

2,4-difluorophenylacetic acid (81228-09-3) → methyl bromo(2,4-difluorophenyl)acetate (1266680-51-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 18 h / 20 °C / Reflux

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 16 h / 20 °C / Reflux

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; In tetrachloromethane;

upstream raw materials:

2,4-difluorophenylacetic acid

methyl 2-(2,4-difluorophenyl)acetate

2-(2,4-difluorophenyl)-2-hydroxyacetic acid

Downstream raw materials:

3-(2,4-difluorophenyl)piperazin-2-one

3-(cyclopropylmethyl)-7-{[3-(2,4-difluorophenyl)piperazin-1-yl]methyl}-8-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine

2-(2,4-difluorophenyl)piperazine

Refernces

• 1、 -. "1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS". . . Retrieved 2012/05/31.