1-(4-fluorophenyl)ethyl-phenylselane

Base Information

• Chemical Name: 1-(4-fluorophenyl)ethyl-phenylselane
• CAS No.: 1415088-80-0
• Molecular Formula: C₁₄H₁₃FSe
• Molecular Weight: 279.216
• Mol file: 1415088-80-0.mol

Synonyms:1-(4-fluorophenyl)ethyl-phenylselane

Chemical Property of 1-(4-fluorophenyl)ethyl-phenylselane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-fluorophenyl)ethyl-phenylselane

There total 2 articles about 1-(4-fluorophenyl)ethyl-phenylselane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

phenyl selenocyanate (2179-79-5) + (R)-1-(4-fluorophenyl)ethan-1-ol (403-41-8,101219-73-2,101219-68-5) → 1-(4-fluorophenyl)ethyl-phenylselane (1415088-80-0)

Guidance literature:

With tributylphosphine; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1016/j.tet.2012.09.087 DOI:10.1016/j.tet.2012.09.087

Reference yield:

1-(4-Fluorophenyl)ethanol (403-41-8) → 1-(4-fluorophenyl)ethyl-phenylselane (1415088-80-0)

Guidance literature:

Multi-step reaction with 3 steps

1: Candida antharctica lipase B / hexane / 24 h / 32 °C / Enzymatic reaction

2: sodium hydroxide; methanol / 1 h

3: tributylphosphine / tetrahydrofuran / 16 h / 20 °C

With methanol; tributylphosphine; Candida antharctica lipase B; sodium hydroxide; In tetrahydrofuran; hexane;

DOI:10.1016/j.tet.2012.09.087 DOI:10.1016/j.tet.2012.09.087

upstream raw materials:

1-(4-Fluorophenyl)ethanol

phenyl selenocyanate

(R)-1-(4-fluorophenyl)ethan-1-ol

Refernces

• 1、 Brondani, Patrícia B.,Guilmoto, Nathalie M.A.F.,Dudek, Hanna M.,Fraaije, Marco W.,Andrade, Leandro H.. "Chemoenzymatic approaches to obtain chiral-centered selenium compounds". . p. 10431 - 10436. Retrieved 2013/01/15.