2,3,4-trimethoxyphenyl acetate

Base Information

• Chemical Name: 2,3,4-trimethoxyphenyl acetate
• CAS No.: 30225-80-0
• Molecular Formula: C₁₁H₁₄O₅
• Molecular Weight: 226.229
• Mol file: 30225-80-0.mol

Synonyms:2,3,4-trimethoxyphenyl acetate

Chemical Property of 2,3,4-trimethoxyphenyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,4-trimethoxyphenyl acetate

There total 5 articles about 2,3,4-trimethoxyphenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2',3',4'-trimethoxyacetophenone (13909-73-4) → 2,3,4-trimethoxyphenyl acetate (30225-80-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; Reflux; Inert atmosphere;

DOI:10.1002/cmdc.201200561

Reference yield:

2,3,4-trimethoxyphenol (19676-64-3) + acetic anhydride (108-24-7) → 2,3,4-trimethoxyphenyl acetate (30225-80-0)

Guidance literature:

With pyridine; In chloroform; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1038/s41429-018-0114-3

Reference yield:

1,2,3-trimethoxybenzene (634-36-6) + 2-(diacetoxyiodo)mesitylene (33035-41-5) → acetic acid 3,4,5-trimethoxy-phenyl ester (17742-46-0) + 2,3,4-trimethoxyphenyl acetate (30225-80-0)

Guidance literature:

With acridine; palladium diacetate; In acetic anhydride; acetic acid; at 100 ℃; for 17h; Reagent/catalyst; Overall yield = 38 %; Overall yield = 97.4 mg;

DOI:10.1021/ol4024248

upstream raw materials:

2',3',4'-trimethoxyacetophenone

1,2,3-trimethoxybenzene

2-(diacetoxyiodo)mesitylene

[bis(acetoxy)iodo]benzene

Downstream raw materials:

C₁₉H₁₈O₆

C₁₉H₂₀N₂O₅

C₁₉H₂₀N₂O₆

C₂₁H₂₄N₂O₇

Refernces

• 1、 Zaninetti, Roberta,Cortese, Salvatore V.,Aprile, Silvio,Massarotti, Alberto,Canonico, Pier Luigi,Sorba, Giovanni,Grosa, Giorgio,Genazzani, Armando A.,Pirali, Tracey. "A Concise Synthesis of Pyrazole Analogues of CombretastatinA1 as Potent Anti-Tubulin Agents". supporting information. p. 633 - 643. Retrieved 2013/08/22.
• 2、 Syper, Ludwik. "The Baeyer-Villiger Oxidation of Aromatic Aldehydes and Ketones with Hydrogen Peroxide Catalyzed by Selenium Compounds". . p. 167 - 172. Retrieved 2007/10/02.