Technology Process of ((1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclohexyl)((R)-3-methylmorpholino)methanone
There total 8 articles about ((1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclohexyl)((R)-3-methylmorpholino)methanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ammonium acetate;
In
toluene;
at 100 ℃;
for 6h;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux
2: palladium on activated charcoal; hydrogen / methanol / 18 h / 50 °C / 9500.64 Torr
3: triethylamine / dichloromethane / 0.5 h / 0 °C
4: acetonitrile / 5 h / 20 °C / Inert atmosphere
5: ammonium acetate / toluene / 6 h / 100 °C / Sealed tube
With
lithium aluminium tetrahydride; palladium on activated charcoal; ammonium acetate; hydrogen; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: palladium on activated charcoal; hydrogen / methanol / 18 h / 50 °C / 9500.64 Torr
2: triethylamine / dichloromethane / 0.5 h / 0 °C
3: acetonitrile / 5 h / 20 °C / Inert atmosphere
4: ammonium acetate / toluene / 6 h / 100 °C / Sealed tube
With
palladium on activated charcoal; ammonium acetate; hydrogen; triethylamine;
In
methanol; dichloromethane; toluene; acetonitrile;