N-(4-methylphenyl)trifluoroacetohydrazonoyl bromide

Base Information

• Chemical Name: N-(4-methylphenyl)trifluoroacetohydrazonoyl bromide
• CAS No.: 98664-40-5
• Molecular Formula: C₉H₈BrF₃N₂
• Molecular Weight: 281.075
• Mol file: 98664-40-5.mol

Synonyms:N-(4-methylphenyl)trifluoroacetohydrazonoyl bromide

Chemical Property of N-(4-methylphenyl)trifluoroacetohydrazonoyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-methylphenyl)trifluoroacetohydrazonoyl bromide

There total 3 articles about N-(4-methylphenyl)trifluoroacetohydrazonoyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trifluoroacetaldehyde 4-methylphenylhydrazone (98664-42-7) → N-(4-methylphenyl)trifluoroacetohydrazonoyl bromide (98664-40-5)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1016/j.jfluchem.2016.10.018

Reference yield:

N-4-methylphenylhydrazine (539-44-6) → N-(4-methylphenyl)trifluoroacetohydrazonoyl bromide (98664-40-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent

2: 67 percent / N-bromosuccinimide / dimethylformamide

With N-Bromosuccinimide; In N,N-dimethyl-formamide;

Reference yield:

p-tolylhydrazine hydrochloride (637-60-5,35467-65-3) → N-(4-methylphenyl)trifluoroacetohydrazonoyl bromide (98664-40-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / ethanol / 2 h / Reflux

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.5 h / 20 °C

With N-Bromosuccinimide; sodium acetate; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

trifluoroacetaldehyde 4-methylphenylhydrazone

N-4-methylphenylhydrazine

p-tolylhydrazine hydrochloride

Downstream raw materials:

2,2,2-trifluoro-N'-(p-tolyl)acetohydrazonamide

2-(1-(p-tolyl)-3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl)pyridine

2-methyl-5-(5-(pyridin-2-yl)-3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl)benzene-1-sulfonyl chloride

2-methyl-5-(5-(pyridin-2-yl)-3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl)benzenethiol

Refernces

• 1、 Utecht-Jarzyńska, Greta,Mykhaylychenko, Sergiy S.,Rusanov, Eduard B.,Shermolovich, Yuriy G.,Jasiński, Marcin,Mlostoń, Grzegorz. "Highly fluorinated 2,3-dihydro-1,3,4-thiadiazole derivatives via [3+2]-cycloadditions of tertiary thioamides with nitrile imines derived from trifluoroacetonitrile". . . Retrieved 2021/01/07.
• 2、 Utecht-Jarzyńska, Greta,Michalak, Aleksandra,Bana?, Justyna,Mlostoń, Grzegorz,Jasiński, Marcin. "Trapping of trifluoroacetonitrile imines with mercaptoacetaldehyde and mercaptocarboxylic acids: An access to fluorinated 1,3,4-thiadiazine derivatives via (3+3)-annulation". . p. 8 - 14. Retrieved 2019/04/25.