2-L-leucylmethotrexate

Base Information

• Chemical Name: 2-L-leucylmethotrexate
• CAS No.: 125507-16-6
• Molecular Formula: C₂₆H₃₃N₉O₆
• Molecular Weight: 567.605
• Mol file: 125507-16-6.mol

Synonyms:2-L-leucylmethotrexate

Chemical Property of 2-L-leucylmethotrexate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-L-leucylmethotrexate

There total 5 articles about 2-L-leucylmethotrexate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → 2-L-leucylmethotrexate (125507-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide / ethyl acetate / 7 h / 45 °C

2: trifluoroacetic acid / Ambient temperature

With dicyclohexyl-carbodiimide; trifluoroacetic acid; In ethyl acetate;

Reference yield:

di-tert-butyl L-glutamate (16874-06-9) → 2-L-leucylmethotrexate (125507-16-6)

Guidance literature:

Multi-step reaction with 3 steps

1: method described in literature

2: dicyclohexylcarbodiimide / ethyl acetate / 7 h / 45 °C

3: trifluoroacetic acid / Ambient temperature

With dicyclohexyl-carbodiimide; trifluoroacetic acid; In ethyl acetate;

Reference yield:

p-methylaminobenzoate → 2-L-leucylmethotrexate (125507-16-6)

Guidance literature:

Multi-step reaction with 3 steps

1: method described in literature

2: dicyclohexylcarbodiimide / ethyl acetate / 7 h / 45 °C

3: trifluoroacetic acid / Ambient temperature

With dicyclohexyl-carbodiimide; trifluoroacetic acid; In ethyl acetate;

upstream raw materials:

di-t-butyl ester of 2-(t-BOC-L-leucyl)methotrexate

N-tert-butoxycarbonyl-L-leucine

di-tert-butyl L-glutamate

methotrexate di-t-butyl ester

Downstream raw materials:

N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid

Refernces