(R)-Piperidine-3-carboxylic acid ethyl ester hydrochloride

Base Information

• Chemical Name: (R)-Piperidine-3-carboxylic acid ethyl ester hydrochloride
• CAS No.: 37675-19-7
• Molecular Formula: C₈H₁₅NO₂*ClH
• Molecular Weight: 193.674
• Hs Code.: 2933399090
• Mol file: 37675-19-7.mol

Synonyms:3-Piperidinecarboxylicacid, ethyl ester, hydrochloride, (3R)- (9CI);3-Piperidinecarboxylic acid,ethyl ester, hydrochloride, (R)-;

Chemical Property of (R)-Piperidine-3-carboxylic acid ethyl ester hydrochloride

Chemical Property:

• Vapor Pressure: 0.014mmHg at 25°C
• Boiling Point: 254 °C at 760 mmHg
• Flash Point: 107.4 °C
• PSA: 38.33000
• LogP: 1.67990
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(R)-Ethylpiperidine-3-carboxylatehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-Piperidine-3-carboxylic acid ethyl ester hydrochloride

There total 7 articles about (R)-Piperidine-3-carboxylic acid ethyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + nipecotic acid (498-95-3,262853-93-0) → ethyl piperidine-3-carboxylate hydrochloride (4842-86-8,37675-19-7)

Guidance literature:

With thionyl chloride; at 0 ℃; Reflux;

Reference yield: 95.0%

(S)-(+)-nipecotic acid ethyl ester (37675-18-6) → (S)-piperidine-3-carboxylic acid ethyl ester hydrochloride (37675-19-7)

Guidance literature:

With hydrogenchloride; In water; toluene; at 60 ℃; Cooling;

Reference yield: 94.0%

ethyl 1-methylpiperidine-3-carboxylate (5166-67-6) → ethyl piperidine-3-carboxylate hydrochloride (4842-86-8,37675-19-7)

Guidance literature:

With aluminum oxide; silica gel; potassium carbonate; sodium percarbonate; sodium salt of 2,4-dichloro-6-hydroxy-1,3,5-triazine; In chloroform; column chromatography;

DOI:10.1021/ol036319g

upstream raw materials:

ethyl 1-methylpiperidine-3-carboxylate

ethanol

nipecotic acid

ethyl N-(t-butyloxycarbonyl)nipecotate

Refernces

• 1、 -. "SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF". Page/Page column 30; 31. . Retrieved 2018/03/28.
• 2、 -. "PROCESS FOR PREPARING ENANTIOMERICALLY ENRICHED 3-HYDROXYMETHYLPIPERIDINE". Page/Page column 16. . Retrieved 2014/11/13.