4-Vinylbenzylamine

Base Information

• Chemical Name: 4-Vinylbenzylamine
• CAS No.: 50325-49-0
• Molecular Formula: C9H11 N
• Molecular Weight: 133.193
• Hs Code.: 2921499090
• European Community (EC) Number: 678-341-5
• DSSTox Substance ID: DTXSID70454137
• Nikkaji Number: J394.321F
• Wikidata: Q72516327
• Mol file: 50325-49-0.mol

Synonyms:4-Vinylbenzylamine;50325-49-0;(4-Vinylphenyl)methanamine;(4-VINYLBENZYL) AMINE;(4-ethenylphenyl)methanamine;4-Vinylbenzylamine (stabilized with MEHQ);p-vinylbenzylamine;4-(Aminomethyl)styrene;Benzenemethanamine, 4-ethenyl-;4-aminomethylstyrene;4-vinyl-benzylamine;SCHEMBL248455;DTXSID70454137;WAVDSLLYAQBITE-UHFFFAOYSA-N;CK2398;MFCD08704374;AKOS006338110;1-(4-ETHENYLPHENYL)METHANAMINE;AS-45898;V0101;52831-01-3

Chemical Property of 4-Vinylbenzylamine

Chemical Property:

• Vapor Pressure: 0.062mmHg at 25°C
• Refractive Index: 1.5750 to 1.5790
• Boiling Point: 60 °C / 1mmHg
• PKA: 9.10±0.10(Predicted)
• Flash Point: 95.998°C
• PSA: 26.02000
• Density: 0.98
• LogP: 2.48860
• Storage Temp.: Refrigerator
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 133.089149355
• Heavy Atom Count: 10
• Complexity: 101

Purity/Quality:

95% ^*data from raw suppliers

(4-Vinylphenyl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C=CC1=CC=C(C=C1)CN

Technology Process of 4-Vinylbenzylamine

There total 3 articles about 4-Vinylbenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-(azidomethyl)-4-vinylbenzene (111965-73-2) → p-vinylbenzylamine (50325-49-0)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; chemoselective reaction;

DOI:10.1021/acscatal.6b01217

Reference yield: 97.0%

2-(4-ethenylbenzyl)-1H-isoindole-1,3(2H)-dione (63413-74-1) → p-vinylbenzylamine (50325-49-0)

Guidance literature:

With hydrazine hydrate;

DOI:10.1002/pola.26584

Reference yield:

4-Vinylbenzyl chloride (1592-20-7,29296-32-0) → p-vinylbenzylamine (50325-49-0)

Guidance literature:

With hydrogenchloride; potassium hydride; 1,1,3,3-tetramethyldisilazane; Yield given. Multistep reaction; 1.) THF, 1 h, 0 deg C; 1 h, r.t.;

DOI:10.1055/s-1995-3875

upstream raw materials:

4-Vinylbenzyl chloride

2-(4-ethenylbenzyl)-1H-isoindole-1,3(2H)-dione

1-(azidomethyl)-4-vinylbenzene

Downstream raw materials:

p-[2-[N-(p-vinylbenzyl)carbamoyl]ethyl]phenyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside

p-[2-[N-(p-vinylbenzyl)carbamoyl]ethyl]phenyl 4-O-acetyl-2-deoxy-3,6-di-O-pivaloyl-β-D-arabino-hexopyranoside

p-[2-[N-(p-vinylbenzyl)carbamoyl]ethyl]phenyl 4-O-acetyl-2-deoxy-2-fluoro-3,6-di-O-pivaloyl-β-D-mannopyranoside

p-[2-[N-(p-vinylbenzyl)carbamoyl]ethyl]phenyl 2-acetamido-2-deoxy-4-O-acetyl-3,6-di-O-pivaloyl-β-D-mannopyranoside

Refernces

• 1、 Audouin, Fabrice,Knoop, Ruther J. I.,Huang, Jin,Heise, Andreas. "Star polymers by cross-linking of linear poly(benzyl-L -glutamate) macromonomers via free-radical and RAFT polymerization. A simple route toward peptide-stabilized nanoparticles". . p. 4602 - 4610. Retrieved 2010.
• 2、 Hayama, Riho,Koyama, Tetsuo,Matsushita, Takahiko,Hatano, Ken,Matsuoka, Koji. "Preparation of functional monomers as precursors of bioprobes from a common styrene derivative and polymer synthesis". . . Retrieved 2018/11/24.
• 3、 Udumula, Venkatareddy,Nazari, S. Hadi,Burt, Scott R.,Alfindee, Madher N.,Michaelis, David J.. "Chemo- and Site-Selective Alkyl and Aryl Azide Reductions with Heterogeneous Nanoparticle Catalysts". . p. 4423 - 4427. Retrieved 2016/07/12.