2-AMINO-5-METHOXYBENZOTRIFLUORIDE

Base Information

• Chemical Name: 2-AMINO-5-METHOXYBENZOTRIFLUORIDE
• CAS No.: 53903-49-4
• Molecular Formula: C8H8F3N
• Molecular Weight: 191.153
• Hs Code.: 2922299090
• Mol file: 53903-49-4.mol

Synonyms:2-Trifluoromethyl-4-methoxyaniline;4-Amino-3-trifluoromethylanisole;4-Methoxy-2-trifluoromethylaniline;

Chemical Property of 2-AMINO-5-METHOXYBENZOTRIFLUORIDE

Chemical Property:

• Vapor Pressure: 0.053mmHg at 25°C
• Refractive Index: 1.477
• Boiling Point: 234.491 °C at 760 mmHg
• PKA: 2.06±0.10(Predicted)
• Flash Point: 95.617 °C
• PSA: 35.25000
• Density: 1.281 g/cm³
• LogP: 2.87740
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methoxy-2-(trifluoromethyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-METHOXYBENZOTRIFLUORIDE

There total 6 articles about 2-AMINO-5-METHOXYBENZOTRIFLUORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxy-1-nitro-2-(trifluoromethyl)benzene (344-39-8) → 4-methoxy-2-(trifluoromethyl)benzenamine (53903-49-4)

Guidance literature:

With nitrogen; hydrogen; palladium; In ethanol;

Reference yield: 93.0%

Togni's reagent II (887144-94-7) + 4-methoxy-aniline (104-94-9) → 4-methoxy-2-(trifluoromethyl)benzenamine (53903-49-4)

Guidance literature:

With potassium carbonate; In acetonitrile; at 75 ℃; for 6h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tetlet.2019.151538

Reference yield:

iodotrifluoromethane (2314-97-8,263005-66-9) + 4-methoxy-aniline (104-94-9) → 4-methoxy-2-(trifluoromethyl)benzenamine (53903-49-4)

Guidance literature:

With tetrabutylammonium perchlorate; C₁₇H₃₂Br₂CoN₄O₂; In dimethyl sulfoxide; at 20 ℃; for 12h; Time; Inert atmosphere; Electrolysis; Irradiation;

DOI:10.1039/d0dt01377c

upstream raw materials:

4-methoxy-1-nitro-2-(trifluoromethyl)benzene

3-Trifluoromethylphenol

3-trifluoromethyl-4-nitrophenol

Togni's reagent II

Downstream raw materials:

4-methoxy-6-(methylthiomethyl)-2-(α,α,α-trifluoromethyl)aniline

2-fluoro-4-(4-methoxy-2-(trifluoromethyl)-phenylamino)-benzonitrile

2-fluoro-4-(4-methoxy-2-(trifluoromethyl)-phenylamino)-benzylamine

(S)-6-oxo-1,6-dihydro-pyridazine-4-carboxylic acid-{3-[2-fluoro-4-(4-methoxy-2-(trifluoromethyl)-phenylamino)-benzylcarbamoyl]-tetrahydrofuran-3-yl}-amide

Refernces

• 1、 Chen, Xiaoyu,Ding, Licheng,Li, Linlin,Li, Jingya,Zou, Dapeng,Wu, Yangjie,Wu, Yusheng. "Transition metal-free direct C–H trifluoromethyltion of (hetero)arenes with Togni's reagent". supporting information. . Retrieved 2019/12/30.
• 2、 -. "Pyrimidine heterocyclic compounds, preparation method and application thereof". Paragraph 0150; 0151; 0154; 0155. . Retrieved 2018/03/25.