4-(3-methoxy-styryl)-pyridine

Base Information

• Chemical Name: 4-(3-methoxy-styryl)-pyridine
• CAS No.: 31338-30-4
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.263
• Mol file: 31338-30-4.mol

Synonyms:4-(3-methoxy-styryl)-pyridine

Chemical Property of 4-(3-methoxy-styryl)-pyridine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(3-methoxy-styryl)-pyridine

There total 8 articles about 4-(3-methoxy-styryl)-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(E)-4-((3-hydroxylphenyl)vinyl)pyridine (77377-05-0) + methyl iodide (74-88-4) → 1-(4-pyridyl)-2-(3-methoxyphenyl)ethene (31338-30-4,147808-68-2)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 2h;

DOI:10.1002/anie.201806076

Reference yield: 79.0%

3-methoxystyrene (626-20-0) + 4-bromopyridin (1120-87-2) → 1-(4-pyridyl)-2-(3-methoxyphenyl)ethene (31338-30-4,147808-68-2)

Guidance literature:

With diamminedichloropalladium(II); tributyl-amine; tetrabutylammomium bromide; In water; at 140 ℃; for 1.5h; Inert atmosphere; Sealed tube; Microwave irradiation;

DOI:10.1039/c5md00197h

Reference yield: 74.0%

4-vinylpyridine (100-43-6,329041-72-7) + 3-methoxyphenylboronic acid (10365-98-7,1107579-37-2) → 1-(4-pyridyl)-2-(3-methoxyphenyl)ethene (31338-30-4,147808-68-2)

Guidance literature:

With palladium(II) acetylacetonate; oxygen; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 90 ℃; for 24h; under 760.051 Torr;

DOI:10.3184/174751912X13352864811920

upstream raw materials:

4-vinylpyridine

3-methoxyphenylboronic acid

3-methoxystyrene

4-bromopyridin

Refernces

• 1、 Cao, Chao-Tun,Yan, Lu,Cao, Chenzhong. "Determination and application of the excited-state substituent constants of pyridyl and substituted phenyl groups". . . Retrieved 2021/05/21.
• 2、 Hu, Fei-Long,Mi, Yan,Zhu, Chen,Abrahams, Brendan F.,Braunstein, Pierre,Lang, Jian-Ping. "Stereoselective Solid-State Synthesis of Substituted Cyclobutanes Assisted by Pseudorotaxane-like MOFs". supporting information. p. 12696 - 12701. Retrieved 2018/09/11.