ETHYL 1-CYANOCYCLOPROPANECARBOXYLATE

Base Information

• Chemical Name: ETHYL 1-CYANOCYCLOPROPANECARBOXYLATE
• CAS No.: 1558-81-2
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• Hs Code.: 2926909090
• Mol file: 1558-81-2.mol

Synonyms:Ethyl 1-cyanocyclopropanecarboxylate;1-Cyano-cyclopropanecarboxylicacid ethyl ester;Ethyl 1-cyanocyclopropane-1-carboxylate;Ethyl1-cyanocyclopropanecarboxylate;NSC 666530;

Chemical Property of ETHYL 1-CYANOCYCLOPROPANECARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.0996mmHg at 25°C
• Refractive Index: n20/D 1.445(lit.)
• Boiling Point: 222.8 °C at 760 mmHg
• Flash Point: 94.9 °C
• PSA: 50.09000
• Density: 1.12 g/cm³
• LogP: 0.85328
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

96% 1H NMR ^*data from raw suppliers

Ethyl1-cyanocyclopropanecarboxylate ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 1-cyano-1-cyclopropanecarboxylate may be used as a monomer in the preparation of poly(ethyl trimethylene-1-cyano-1-carboxylate)s.

Technology Process of ETHYL 1-CYANOCYCLOPROPANECARBOXYLATE

There total 8 articles about ETHYL 1-CYANOCYCLOPROPANECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethylene dibromide (106-93-4) + ethyl 2-cyanoacetate (105-56-6) → 1-carbethoxy-1-cyanocyclopropane (1558-81-2)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 8h;

Reference yield: 90.0%

1,2-dichloro-ethane (107-06-2,52399-93-6) + ethyl 2-cyanoacetate (105-56-6) → 1-carbethoxy-1-cyanocyclopropane (1558-81-2)

Guidance literature:

With tetrabutylammomium bromide; cyclohexene; Mechanism; electrolysis (platinum cathode, carbon anode);

DOI:10.1007/BF00959604

Reference yield: 82.0%

S-ethenyl-S-(4-methylphenyl)-N-tosylsulfilimine (64648-13-1,81115-85-7,81115-90-4) + ethyl 2-cyanoacetate (105-56-6) → 1-carbethoxy-1-cyanocyclopropane (1558-81-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 24h;

upstream raw materials:

ethylene dibromide

ethyl 2-cyanoacetate

ethanol

(2-Dimethylsulfonio-ethyl)-malononitril-Kation

Downstream raw materials:

diethyl 2-chloroethylmalonate

cyclopropane-1,1-dicarboxylic acid

Cyclopropan-1-carbonsaeureethylester-1-carbonsaeureamid

diethyl cyclopropane-1,1-dicarboxylate

Refernces

• 1、 Kagumba, Lawino C.,Penelle, Jacques. "Anionic ring-opening polymerization of alkyl 1- cyanocyclopropanecarboxylates". . p. 4588 - 4594. Retrieved 2005.
• 2、 Vasil'ev, A. A.,Tatarinova, V. I.,Petrosyan, V. A.. "CATHODIC SYNTHESIS OF CYCLOPROPANE DERIVATIVES BY THE ELECTROLYSIS OF COMPOUNDS WITH AN ACTIVATED METHYLENE GROUP IN 1,2-DICHLOROETHANE". . p. 631 - 633. Retrieved 1990.
• 3、 -. "MACROCYCLIC COMPOUNDS AS STING AGONISTS AND METHODS AND USES THEREOF". Paragraph 0306-0307. . Retrieved 2021/01/29.
• 4、 -. "Quinazolinone Compound and Application Thereof". Paragraph 0760-0762. . Retrieved 2020/11/27.