4-BENZYLOXYIODOBENZENE

Base Information

• Chemical Name: 4-BENZYLOXYIODOBENZENE
• CAS No.: 19578-68-8
• Molecular Formula: C13H11IO
• Molecular Weight: 310.134
• Hs Code.: 29093090
• Mol file: 19578-68-8.mol

Synonyms:Ether,benzyl p-iodophenyl (6CI,8CI);((4-Iodophenoxy)methyl)benzene;1-Benzyloxy-4-iodobenzene;1-Iodo-4-(phenylmethoxy)benzene;4-(Benzyloxy)iodobenzene;4-Benzyloxy-1-iodobenzene;4-Benzyloxyphenyl iodide;4-Iodophenyl phenylmethyl ether;

Chemical Property of 4-BENZYLOXYIODOBENZENE

Chemical Property:

• Vapor Pressure: 4.72E-05mmHg at 25°C
• Melting Point: 60-63 °C(lit.)
• Refractive Index: 1.635
• Boiling Point: 360.071 °C at 760 mmHg
• Flash Point: 171.565 °C
• PSA: 9.23000
• Density: 1.581 g/cm³
• LogP: 3.87020
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Light Sensitive
• Water Solubility.: Insoluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Benzyloxyiodobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Benzyloxy-4-iodobenzene is used as an emulgator and as a pharmaceutical intermediate. 4-Benzyloxyiodobenzene is a research reagent used in the synthesis and biological evaluation of GPR40 agonist with nitrogen heterocyclic rings. A pharmaceutical intermediate.

Technology Process of 4-BENZYLOXYIODOBENZENE

There total 8 articles about 4-BENZYLOXYIODOBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-Iodophenol (540-38-5) + benzyl chloride (100-44-7) → 4-(4-benzyloxyphenyl) iodide (19578-68-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

Reference yield: 99.0%

p-Iodophenol (540-38-5) + benzyl bromide (100-39-0) → 4-(4-benzyloxyphenyl) iodide (19578-68-8)

Guidance literature:

With potassium carbonate; In acetone; for 24h; Reflux;

DOI:10.1016/j.tet.2014.10.010

Reference yield: 96.0%

(benzyloxy)benzene (946-80-5) → 4-(4-benzyloxyphenyl) iodide (19578-68-8)

Guidance literature:

With iodine; mercury(II) oxide; In dichloromethane; at 20 ℃; for 26h;

DOI:10.1002/(SICI)1099-1344(200004)43:5<505::AID-JLCR336>3.0.CO;2-0

upstream raw materials:

p-Iodophenol

sodium ethanolate

benzyl chloride

(benzyloxy)benzene

Downstream raw materials:

1,2-bis(4-benzyloxyphenyl)acetylene

(S)-N-(tert-butoxycarbonyl)alanine methyl ester

N-tert-butoxycarbonyl-O-benzyl-(S)-tyrosine methyl ester

(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

Refernces

• 1、 Zupan, Marko,Iskra, Jernej,Stavber, Stojan. "Room temperature regioselective iodination of aromatic ethers mediated by Selectfluor(TM) reagent F-TEDA-BF4". . p. 6305 - 6306. Retrieved 1997.
• 2、 Huang, Binbin,Guo, Lin,Xia, Wujiong. "A facile and versatile electro-reductive system for hydrodefunctionalization under ambient conditions". supporting information. p. 2095 - 2103. Retrieved 2021/03/26.
• 3、 Joo, Seong-Ryu,Kim, Seung-Hoi,Kwon, Gyu-Tae,Park, Soo-Youl. "Choline Hydroxide as a Versatile Medium for Catalyst-Free O-Functionalization of Phenols". . p. 1200 - 1205. Retrieved 2020/11/30.