3-AMINOIMIDAZO(1,2-A)PYRIDINE

Base Information

• Chemical Name: 3-AMINOIMIDAZO(1,2-A)PYRIDINE
• CAS No.: 28036-33-1
• Molecular Formula: C7H7N3
• Molecular Weight: 133.153
• Hs Code.: 2933990090
• Mol file: 28036-33-1.mol

Synonyms:Imidazo[1,2-a]pyridine,3-amino- (8CI);NSC 305196;

Chemical Property of 3-AMINOIMIDAZO(1,2-A)PYRIDINE

Chemical Property:

• Melting Point: 114-126 °C
• Refractive Index: 1.696
• PKA: 8.01±0.50(Predicted)
• PSA: 43.32000
• Density: 1.32 g/cm³
• LogP: 1.49770
• Storage Temp.: 2-8°C
• Water Solubility.: Slightly Soluble in water. (4.9 g/L) (25°C)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Imidazo[1,2-a]pyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the production of mutagenic pyrolyzates. It is an intermediate in the production of mutagenic pyrolyzates.

Technology Process of 3-AMINOIMIDAZO(1,2-A)PYRIDINE

There total 6 articles about 3-AMINOIMIDAZO(1,2-A)PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

N-(diphenylmethylidene)imidazo[1,2-a]pyridin-3-amine → 3-aminoimidazo<1,2-a>pyridine (28036-33-1)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 12h;

Reference yield:

3-iodo-imidazo[1,2-a]pyridine (307503-19-1) → 3-aminoimidazo<1,2-a>pyridine (28036-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 5 h / 80 °C

2: hydrogenchloride / water / 12 h / 20 °C

With hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In water; toluene;

Reference yield:

2-aminopyridine (504-29-0) → 3-aminoimidazo<1,2-a>pyridine (28036-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bismuth(III) chloride / water; ethanol / 0.33 h / 25 °C

1.2: 1.5 h / Reflux

2.1: water; ethanol / 4 h / Heating

With bismuth(III) chloride; In ethanol; water;

DOI:10.1021/acs.jmedchem.7b01484

upstream raw materials:

2-aminopyridine

formaldehyd

potassium cyanide

3-iodo-imidazo[1,2-a]pyridine

Downstream raw materials:

N-(imidazo[1,2-a]pyridin-3-yl)-4-methoxy-2,3,6-trimethylbenzenesulfonamide

3-amino-2-(4-nitrophenylazo)imidazo<1,2-a>pyridine

pyrido[3',2':4,5]imidazo[1,2-a]pyridine

C₂₃H₁₇N₃O

Refernces

• 1、 -. "AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS AS EHMT1 AND EHMT2 INHIBITORS". . . Retrieved 2017/11/10.