phenyl isocyanate

Base Information

• Chemical Name: phenyl isocyanate
• CAS No.: 1197040-29-1
• Molecular Formula: C₇H₅N
• Molecular Weight: 103.123
• Mol file: 1197040-29-1.mol

Synonyms:phenyl isocyanate

Chemical Property of phenyl isocyanate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl isocyanate

There total 129 articles about phenyl isocyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

monophenylthiourea (103-85-5) → phenyl isocyanate (1197040-29-1,931-54-4) + phenyl carbamate (64-10-8)

Guidance literature:

With cetyl-trimethylammonium dichromate; chemoselective reaction; Microwave irradiation;

DOI:10.1080/00397910903398684

Reference yield: 21.0%

tributylstannylethynylbenzene (3757-88-8) + phenylcarbonimidic dichloride (622-44-6) → phenyl isocyanate (1197040-29-1,931-54-4) + 1,4-diphenyl-1,3-butadiyne (886-66-8) + Phenyl-(3-phenyl-1-phenylethynyl-prop-2-ynylidene)-amine (122016-23-3)

Guidance literature:

bis-triphenylphosphine-palladium(II) chloride; In benzene; at 70 ℃; for 5h;

DOI:10.1016/S0040-4039(00)82873-7

Reference yield: 12.5%

chloroform (67-66-3,8013-54-5) + aniline (62-53-3) → dichloromethane (75-09-2) + phenyl isocyanate (1197040-29-1,931-54-4) + Azobenzene (1227476-15-4) + N-phenylphenylene-1,4-diamine (101-54-2) + N-phenyl-1,2-benzenediamine (534-85-0) + 1,1,2,2-tetrachloroethane (79-34-5)

Guidance literature:

at 15 ℃; for 24h; Product distribution; Mechanism; Irradiation;

upstream raw materials:

pyridine

(E)-benzil monooxime

benzenesulfonyl chloride

α-picoline

Downstream raw materials:

diethyl ether

1-phenyl-3-methyl-4-phenylaminomethylene-5-pyrazolone

3,3,3-trichloro-2-hydroxy-propionic acid anilide

β,β-dichloro-α-hydroxy-isobutyric acid anilide

Refernces

• 1、 Wallach. "-". . . Retrieved 1872.
• 2、 Guirado, Antonio,Zapata, Andrés,Andreu, Raquel,Martiz, Bruno. "Electrochemical reduction of diheteroaryl-1,2-diketones in the presence of carbonimidoyl dichlorides. First synthesis of 2-arylimino-4,5-di-2-furyl-1,3-dioxoles and (E)-1,2-di-2-furylvinylene bis(N-arylchloroformimidates)". . p. 1405 - 1408. Retrieved 2002.
• 3、 Dong, Ru,Zhang, Cheng,Wang, Chao,Zhou, Xin,Li, Wen,Zhang, Jin-Yang,Wang, Min,Xu, Yong,Sun, Li-Ping. "Design, synthesis and anticancer evaluation of 3-methyl-1H-indazole derivatives as novel selective bromodomain-containing protein 4 inhibitors". . . Retrieved 2022/01/11.
• 4、 -. "Application of proteasome inhibitor in inhibition of novel coronavirus". Paragraph 0091; 0110-0112; 0130; 0152-0154. . Retrieved 2021/06/22.