Z-D-TYR-OH

Base Information

• Chemical Name: Z-D-TYR-OH
• CAS No.: 64205-12-5
• Molecular Formula: C17H17 N O5
• Molecular Weight: 315.326
• Hs Code.: 2924299090
• Mol file: 64205-12-5.mol

Synonyms:D-(Carbobenzyloxy)tyrosine;N-Benzyloxycarbonyl-D-tyrosine; N-Carbobenzyloxy-D-tyrosine

Chemical Property of Z-D-TYR-OH

Chemical Property:

• Vapor Pressure: 7.21E-14mmHg at 25°C
• Melting Point: 99 °C
• Boiling Point: 570.8oC at 760 mmHg
• PKA: 2.97±0.10(Predicted)
• Flash Point: 299oC
• PSA: 95.86000
• Density: 1.323g/cm3
• LogP: 2.70520
• Storage Temp.: Store at RT.
• Solubility.: soluble in Methanol

Purity/Quality:

99%, ^*data from raw suppliers

Z-D-tyrosine 99+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Cbz-D-tyrosine is an N-Cbz-protected form of D-Tyrosine (T899970). D-Tyrosine is an unnatural isomer of L-Tyrosine (T899975) that inhibits metabolic activity of Bacillus subtilis. It is known to exhibit antimetabolic effects on rats as well, inhibiting growth and development. D-Tyrosine is also a chiral precursor to biosynthesized inhibitors that have antiinflammatory effects in humans.

Technology Process of Z-D-TYR-OH

There total 4 articles about Z-D-TYR-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethanol (64-17-5) + N-α-benzyloxycarbonyl-DL-tyrosine (5618-98-4) → N-[(phenylmethoxy)carbonyl]-L-tyrosine (16679-94-0) + N-α-benzyloxycarbonyl-D-tyrosine (64205-12-5)

Guidance literature:

With citrate buffer; DL-cysteine hydrochloride; papain; at 50 ℃; for 24h;

Reference yield:

N-α-benzyloxycarbonyl-DL-tyrosine (5618-98-4) → L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) + N-α-benzyloxycarbonyl-D-tyrosine (64205-12-5)

Guidance literature:

With cell extract of Sphingomonas paucimobilis SC 16113; In water; at 42 ℃; for 20h; Enzymatic reaction;

DOI:10.1002/adsc.200303038

Reference yield:

tyrosine (556-02-5,18875-48-4,25619-78-7,30704-25-7) → N-α-benzyloxycarbonyl-D-tyrosine (64205-12-5)

Guidance literature:

upstream raw materials:

ethanol

N-α-benzyloxycarbonyl-DL-tyrosine

tyrosine

N-(benzyloxycarbonyl)succinimide

Downstream raw materials:

(S)-2-((R)-3-Amino-2-methyl-propionyloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

[(R)-1-Carbamoyl-2-(4-methoxy-phenyl)-ethyl]-carbamic acid benzyl ester

(R)-N-benzyloxycarbonyl tyrosinamide

Refernces

• 1、 Zamri, Adel,Sirockin, Finton,Abdallah, Mohamed A.. "A stereocontrolled synthesis of a new class of 3,4,5,6- tetrahydropyrimidine-based chiral amino acids". . p. 5157 - 5170. Retrieved 2007/10/03.
• 2、 -. "D-amino acid analogs of beta-endorphin". . . Retrieved 2008/06/13.