1-phenyl-2-propyl 2-(methoxyethoxyethylcarboxy)-1-benzosulfonate

Base Information

• Chemical Name: 1-phenyl-2-propyl 2-(methoxyethoxyethylcarboxy)-1-benzosulfonate
• CAS No.: 866942-23-6
• Molecular Formula: C₂₁H₂₆O₇S
• Molecular Weight: 422.499
• Mol file: 866942-23-6.mol

Synonyms:1-phenyl-2-propyl 2-(methoxyethoxyethylcarboxy)-1-benzosulfonate

Chemical Property of 1-phenyl-2-propyl 2-(methoxyethoxyethylcarboxy)-1-benzosulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-phenyl-2-propyl 2-(methoxyethoxyethylcarboxy)-1-benzosulfonate

There total 4 articles about 1-phenyl-2-propyl 2-(methoxyethoxyethylcarboxy)-1-benzosulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(2-methoxy-ethoxy)-ethyl 2-chlorosulfonyl-benzoate (866942-11-2) + 3-phenyl-2-propanol (698-87-3,14898-87-4) → 1-phenyl-2-propyl 2-(methoxyethoxyethylcarboxy)-1-benzosulfonate (866942-23-6)

Guidance literature:

With dmap; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jo051241y

Reference yield: 93.0%

→ 1-phenyl-2-propyl 2-(methoxyethoxyethylcarboxy)-1-benzosulfonate (866942-23-6)

Guidance literature:

Reference yield:

2-sulfobenzoic acid cyclic anhydride (81-08-3) → 1-phenyl-2-propyl 2-(methoxyethoxyethylcarboxy)-1-benzosulfonate (866942-23-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / PCl₅ / 6 h / 90 °C

2: 93 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 0 - 20 °C

With dmap; phosphorus pentachloride; In dichloromethane;

DOI:10.1021/jo051241y

upstream raw materials:

2-(2-methoxy-ethoxy)-ethyl 2-chlorosulfonyl-benzoate

3-phenyl-2-propanol

2-sulfobenzoic acid cyclic anhydride

2-(2-methoxyethoxy)ethyl alcohol

Downstream raw materials:

(2-bromopropyl)-benzene

1-phenyl-2-chloropropane

Refernces

• 1、 Lepore, Salvatore D.,Bhunia, Anjan K.,Cohn, Pamela. "Arylsulfonate-based nucleophile assisting leaving groups". . p. 8117 - 8121. Retrieved 2007/10/03.