FMOC-GLU(ODMAB)-OH

Base Information

• Chemical Name: FMOC-GLU(ODMAB)-OH
• CAS No.: 172611-75-5
• Molecular Formula: C40H44 N2 O8
• Molecular Weight: 680.798
• Mol file: 172611-75-5.mol

Synonyms:N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamic acid 1-[[4-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]phenyl]methyl] ester

Chemical Property of FMOC-GLU(ODMAB)-OH

Chemical Property:

• PSA: 148.10000
• Density: 1.251
• LogP: 7.63610
• Storage Temp.: Store at 0°C

Purity/Quality:

98%Min ^*data from raw suppliers

Fmoc-L-Glu-ODmab ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of FMOC-GLU(ODMAB)-OH

There total 1 articles about FMOC-GLU(ODMAB)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-tert-butyl ester 1-{4-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butylamino]-benzyl} ester → Fmoc-Glu(ODmab)-OH (172611-75-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 2h; Yield given;

DOI:10.1039/c39950002209

Reference yield:

polyethylene glycol polyamide resin + Fmoc-Ile-OH (71989-23-6,251316-98-0) + L-Asn(Trt) (132388-59-1) + Fmoc-Lys(Dde)-OH (150629-67-7) + Fmoc-Glu(ODmab)-OH (172611-75-5) + 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester (143824-78-6,163619-04-3) + (2S,4S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-azidopyrrolidine-2-carboxylic acid (263847-08-1) → C70H88N15O14Pol

Guidance literature:

polyethylene glycol polyamide resin; Fmoc-Lys(Dde)-OH; With ethyl cyanoglyoxylate-2-oxime; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 93 ℃; rink amide resin Microwave irradiation;

With piperidine; benzotriazol-1-ol; In N,N-dimethyl-formamide; rink amide resin Microwave irradiation;

Fmoc-Ile-OH; L-Asn(Trt); Fmoc-Glu(ODmab)-OH; 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester; (2S,4S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-azidopyrrolidine-2-carboxylic acid; Further stages;

DOI:10.1021/acs.jmedchem.5b00935

Reference yield:

polyethylene glycol polyamide resin + Fmoc-Ile-OH (71989-23-6,251316-98-0) + L-Asn(Trt) (132388-59-1) + Fmoc-Lys(Dde)-OH (150629-67-7) + Fmoc-Glu(ODmab)-OH (172611-75-5) + 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester (143824-78-6,163619-04-3) + (2S,4S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-azidopyrrolidine-2-carboxylic acid (263847-08-1) → C85H97N14O17Pol

Guidance literature:

polyethylene glycol polyamide resin; Fmoc-Lys(Dde)-OH; With ethyl cyanoglyoxylate-2-oxime; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 93 ℃; rink amide resin Microwave irradiation;

With piperidine; benzotriazol-1-ol; In N,N-dimethyl-formamide; rink amide resin Microwave irradiation;

Fmoc-Ile-OH; L-Asn(Trt); Fmoc-Glu(ODmab)-OH; 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester; (2S,4S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-azidopyrrolidine-2-carboxylic acid; Further stages;

DOI:10.1021/acs.jmedchem.5b00935

Refernces