Ethyl 2-amino-2-methylpropanoate hydrochloride

Base Information

• Chemical Name: Ethyl 2-amino-2-methylpropanoate hydrochloride
• CAS No.: 17288-15-2
• Molecular Formula: C6H13NO2^.HCl
• Molecular Weight: 167.636
• Hs Code.: 2922499990
• Mol file: 17288-15-2.mol

Synonyms:Alanine,2-methyl-, ethyl ester, hydrochloride (8CI,9CI);Ethyl2-amino-2-methylpropanoate hydrochloride;Ethyl a-aminoisobutyrate hydrochloride;a-Aminoisobutyric acid ethyl esterhydrochloride;a-Methylalanineethyl ester hydrochloride;

Chemical Property of Ethyl 2-amino-2-methylpropanoate hydrochloride

Chemical Property:

• Vapor Pressure: 0.438mmHg at 25°C
• Melting Point: 156-157 °C
• Boiling Point: 191.4 °C at 760 mmHg
• Flash Point: 69.5 °C
• PSA: 52.32000
• LogP: 1.78910
• Storage Temp.: Store at 0-5°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl2-Amino-2-methyl-1-propionateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: As an amino acid derivative, 2-Amino-2-methyl-propionic acid ethyl ester hydrochloride can be used in pharmaceutical compositions. An amino acid derivative used in pharmaceutical compositions.

Technology Process of Ethyl 2-amino-2-methylpropanoate hydrochloride

There total 5 articles about Ethyl 2-amino-2-methylpropanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + 2-Aminoisobutyric acid (62-57-7) → ethyl 2-aminoisobutyrate hydrochloride (17288-15-2)

Guidance literature:

With thionyl chloride; for 1h; Heating;

DOI:10.1071/CH99012

Reference yield: 94.0%

ethanol (64-17-5) + methyl 2-aminoisobutyrate hydrochloride (15028-41-8) → ethyl 2-aminoisobutyrate hydrochloride (17288-15-2)

Guidance literature:

With hydrogenchloride;

DOI:10.1016/0040-4020(82)85164-8

Reference yield: 86.3%

→ ethyl 2-aminoisobutyrate hydrochloride (17288-15-2)

Guidance literature:

upstream raw materials:

ethanol

2-Aminoisobutyric acid

methyl 2-aminoisobutyrate hydrochloride

ethyl 2-((tert-butoxycarbonyl)amino)-2-methylpropanoate

Downstream raw materials:

2-Amino-2-methyl-1,1-diphenyl-propan-1-ol

methyl methacrylate

ethyl 2-hydroxy-2,2-dimethylethanoate

N-Oxanilyl-α-amino-isobuttersaeure-ethylester

Refernces

• 1、 -. "ANTIVIRAL PRODRUGS OF TENOFOVIR". Page/Page column 29; 30; 33. . Retrieved 2018/09/26.
• 2、 -. "METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS". Paragraph 0638-0639. . Retrieved 2017/04/04.