4-Chloro-2-pyridinemethanamine

Base Information

• Chemical Name: 4-Chloro-2-pyridinemethanamine
• CAS No.: 180748-30-5
• Molecular Formula: C6H7ClN2
• Molecular Weight: 142.588
• Hs Code.: 2933399090
• Mol file: 180748-30-5.mol

Synonyms:4-Chloro-2-pyridinemethanamine;(4-Chloropyridin-2-yl)methanamine;2-Aminomethy-4-chloropyridine;4-chloro-2-aminomethylpyridine;2-aminomethyl-4-chloropyridine;(4-chloro-2-pyridyl)methylamine;(4-chloropyridin-2-yl)methylamine;

Chemical Property of 4-Chloro-2-pyridinemethanamine

Chemical Property:

• Vapor Pressure: 0.118mmHg at 25°C
• Refractive Index: 1.572
• Boiling Point: 219.586 °C at 760 mmHg
• PKA: 8.42±0.39(Predicted)
• Flash Point: 86.603 °C
• PSA: 38.91000
• Density: 1.244 g/cm³
• LogP: 1.89400
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-2-pyridinemethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-2-pyridinemethanamine

There total 10 articles about 4-Chloro-2-pyridinemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(azidomethyl)-4-chloropyridine → (4-chloropyridin-2-yl)methanamine (180748-30-5)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 3h; Cooling with ice; Inert atmosphere;

Reference yield: 80.0%

2-phthalimidomethyl-4-chloropyridine (500716-27-8) → (4-chloropyridin-2-yl)methanamine (180748-30-5)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

Reference yield: 62.4%

(4-chloropyridin-2-yl)methanol (63071-10-3) → (4-chloropyridin-2-yl)methanamine (180748-30-5)

Guidance literature:

(4-chloropyridin-2-yl)methanol; With di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; triphenylphosphine; In tetrahydrofuran; at 0 - 55 ℃; Inert atmosphere; Schlenk technique;

With water; at 55 ℃; for 1h;

DOI:10.1021/ic4008685

upstream raw materials:

4-chloro-2-pyridyl aldoxime

4-chloro-2-(chloromethyl)pyridine hydrochloride

(4-chloropyridin-2-yl)methanol

4-chloro-2-pyridinecarbaldehyde

Downstream raw materials:

2-(aminomethyl)-4-(dimethylamino)pyridine

Refernces

• 1、 Li, Maosheng,Zhang, Shuai,Zhang, Xiaoyong,Wang, Yanchao,Chen, Jinlong,Tao, Youhua,Wang, Xianhong. "Unimolecular Anion-Binding Catalysts for Selective Ring-Opening Polymerization of O-carboxyanhydrides". . p. 6003 - 6012. Retrieved 2021.
• 2、 -. "DMAP-thiourea catalyst and preparation method thereof, and high-molecular-weight biodegradable polyester and preparation method thereof". . . Retrieved 2021/07/11.