8-Bromo-4-chromanone

Base Information

• Chemical Name: 8-Bromo-4-chromanone
• CAS No.: 204377-88-8
• Molecular Formula: C₉H₇BrO₂
• Molecular Weight: 227.057
• Hs Code.: 2932999099
• Mol file: 204377-88-8.mol

Synonyms:8-Bromo-4-chromanone;

Chemical Property of 8-Bromo-4-chromanone

Chemical Property:

• Vapor Pressure: 9.21E-05mmHg at 25°C
• Refractive Index: 1.599
• Boiling Point: 339.4 °C at 760 mmHg
• Flash Point: 159.1 °C
• PSA: 26.30000
• Density: 1.621 g/cm³
• LogP: 2.41430
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

8-Bromochroman-4-One ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Bromo-4-chromanone

There total 5 articles about 8-Bromo-4-chromanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-(2-bromophenoxy)propionic acid (165538-35-2) → 8-bromo-3,4-dihydro-2H-1-benzopyran-4-one (204377-88-8)

Guidance literature:

With polyphosphoric acid; for 1h; Heating;

DOI:10.1071/CH10295

Reference yield: 48.0%

1-bromo-2-((3-chloroprop-2-yn-1-yl)oxy)benzene (1403387-58-5) → 8-bromo-3,4-dihydro-2H-1-benzopyran-4-one (204377-88-8)

Guidance literature:

In ethylene glycol; for 4h; Reflux;

Reference yield:

2-hydroxybromobenzene (95-56-7) → 8-bromo-3,4-dihydro-2H-1-benzopyran-4-one (204377-88-8)

Guidance literature:

Multi-step reaction with 3 steps

1: N-benzyl-trimethylammonium hydroxide / methanol / Heating

2: hydrogenchloride; formic acid; water / 24 h / Heating

3: polyphosphoric acid / 1 h / Heating

With hydrogenchloride; formic acid; water; N-benzyl-trimethylammonium hydroxide; In methanol; 1: oxa-Michael addition;

DOI:10.1071/CH10295

upstream raw materials:

3-(2-bromophenoxy)propionitrile

2-hydroxybromobenzene

3-(2-bromophenoxy)propionic acid

1-bromo-2-(prop-2-yn-1-yloxy)benzene

Downstream raw materials:

8-bromo-4H-chromen-4-one

(E)-8-styrylchromone

8-bromo-3,4-dihydro-2H-1-benzopyran

Refernces

• 1、 -. "PYRROLO SULFONAMIDE COMPOUNDS FOR MODULATION OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORGAMMA, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES". . . Retrieved 2012/11/06.