3-(Trifluoromethyl)styrene

Base Information

• Chemical Name: 3-(Trifluoromethyl)styrene
• CAS No.: 402-24-4
• Molecular Formula: C9H7 F3
• Molecular Weight: 172.15
• Hs Code.: 29039990
• Mol file: 402-24-4.mol

Synonyms:Styrene,m-(trifluoromethyl)- (6CI,7CI,8CI); 1-(Trifluoromethyl)-3-vinylbenzene;3-Trifluoromethylstyrene; 3-Vinylbenzotrifluoride;[3-(Trifluoromethyl)phenyl]ethene; m-Trifluoromethylstyrene

Chemical Property of 3-(Trifluoromethyl)styrene

Chemical Property:

• Refractive Index: n20/D 1.465(lit.)
• Boiling Point: 64.5 ºC (40 mmHg)
• Flash Point: 42 ºC
• PSA: 0.00000
• Density: 1.161
• LogP: 3.34840
• Storage Temp.: Refrigerator (+4°C) + Flammables area

Purity/Quality:

97% ^*data from raw suppliers

3-(Trifluoromethyl)styrene ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36/37/39-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(Trifluoromethyl)styrene

There total 18 articles about 3-(Trifluoromethyl)styrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Triethoxyvinylsilane (78-08-0) + m-trifluoromethylphenyl iodide (401-81-0) → 3-(trifluoromethyl)styrene (402-24-4)

Guidance literature:

With sodium hydroxide; In methanol; water; at 100 ℃; for 5h; Sealed tube;

DOI:10.1002/ejoc.201400162

Reference yield: 40.0%

3-Trifluoromethylbenzaldehyde (454-89-7) + Methyltriphenylphosphonium bromide (1779-49-3) → 3-(trifluoromethyl)styrene (402-24-4)

Guidance literature:

3-Trifluoromethylbenzaldehyde; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 0.5h;

Methyltriphenylphosphonium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield: 40.0%

1-(3-trifluoromethylphenyl)ethanol (454-91-1) → 3-(trifluoromethyl)styrene (402-24-4)

Guidance literature:

With phosphorus pentoxide; In benzene; for 4h; Heating;

upstream raw materials:

2-[3-(trifluoromethyl)phenyl]ethanol

1-(3-trifluoromethylphenyl)ethanol

2-(-m-Trifluormethylphenyl)ethylfluorid

vinyllithium

Downstream raw materials:

2-[3-(trifluoromethyl)phenyl]ethanol

(S)-1-(3-trifluoromethylphenyl)ethanol

(R)-1-(3-trifluoromethylphenyl)ethanol

(E)-N-[2-(3-Trifluoromethylphenyl)ethyl]morpholine

Refernces

• 1、 Yang, Qiang,Canturk, Belgin,Gray, Kaitlyn,McCusker, Elizabeth,Sheng, Min,Li, Fangzheng. "Evaluation of Potential Safety Hazards Associated with the Suzuki-Miyaura Cross-Coupling of Aryl Bromides with Vinylboron Species". . p. 351 - 359. Retrieved 2018/03/22.
• 2、 Haubenreisser, Stefan,W?ste, Thorsten H.,Martnez, Claudio,Ishihara, Kazuaki,Muiz, Kilian. "Structurally Defined Molecular Hypervalent Iodine Catalysts for Intermolecular Enantioselective Reactions". supporting information. p. 413 - 417. Retrieved 2016/01/25.