(R)(-)-2-BENZYLAMINO-1-BUTANOL

Base Information

• Chemical Name: (R)(-)-2-BENZYLAMINO-1-BUTANOL
• CAS No.: 6257-49-4
• Molecular Formula: C11H17NO
• Molecular Weight: 179.262
• Hs Code.: 2922199090
• Mol file: 6257-49-4.mol

Synonyms:1-Butanol, 2-[(phenylmethyl)amino]-, (R)-;(R)-(-)-N-Benzyl-2-amino-1-butanol;(R)-2-Benzylamino-1-butanol;(R)-N-Benzyl-2-aminobutanol;

Chemical Property of (R)(-)-2-BENZYLAMINO-1-BUTANOL

Chemical Property:

• Vapor Pressure: 0.000314mmHg at 25°C
• Melting Point: 71-72 °C
• Refractive Index: 1.526
• Boiling Point: 307.5 °C at 760 mmHg
• PKA: 14.59±0.10(Predicted)
• Flash Point: 114.8 °C
• PSA: 32.26000
• Density: 1.004 g/cm³
• LogP: 1.93800

Purity/Quality:

99%, ^*data from raw suppliers

(2R)-2-(benzylamino)butan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)(-)-2-BENZYLAMINO-1-BUTANOL

There total 15 articles about (R)(-)-2-BENZYLAMINO-1-BUTANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(2R)-2-aminobutan-1-ol (5856-63-3) + benzaldehyde (100-52-7) → (2R)-2-(benzylamino)butan-1-ol (6257-49-4,51977-20-9)

Guidance literature:

(2R)-2-aminobutan-1-ol; benzaldehyde; In methanol; at 20 ℃; for 1h; Inert atmosphere;

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c01035

Reference yield: 94.0%

(2R)-2-aminobutan-1-ol (5856-63-3) + benzyl chloride (100-44-7) → (2R)-2-(benzylamino)butan-1-ol (6257-49-4,51977-20-9)

Guidance literature:

With sodium carbonate; at 100 ℃; for 8h;

DOI:10.1016/j.tetasy.2005.07.002

Reference yield: 91.0%

(R)-(+)-N-benzylidene-2-aminobutan-1-ol → (2R)-2-(benzylamino)butan-1-ol (6257-49-4,51977-20-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃;

upstream raw materials:

(-)-2-(benzyl)amino-1-butanol

S-(+)-2-benzoylamino-n-butyric acid

(2R)-2-aminobutan-1-ol

benzyl bromide

Downstream raw materials:

Benzyl-((R)-1-ethyl-4-oxo-butyl)-carbamic acid benzyl ester

Benzyl-((R)-1-formyl-propyl)-carbamic acid benzyl ester

Benzyl-((R)-1-ethyl-4-oxo-undecyl)-carbamic acid benzyl ester

Benzyl-((R)-1-ethyl-4-hydroxy-undecyl)-carbamic acid benzyl ester

Refernces

• 1、 Li, Mao-Lin,Yu, Jin-Han,Li, Yi-Hao,Zhu, Shou-Fei,Zhou, Qi-Lin. "Highly enantioselective carbene insertion into N–H bonds of aliphatic amines". . p. 990 - 994. Retrieved 2019/11/28.
• 2、 Durap, Feyyaz,Aydemir, Murat,Elma, Duygu,Baysal, Akin,Turgut, Yilmaz. "New C2-symmetric chiral phosphinite ligands based on amino alcohol scaffolds and their use in the ruthenium-catalysed asymmetric transfer hydrogenation of aromatic ketones". . p. 363 - 371. Retrieved 2013/08/25.