5-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pentanoic acid

Base Information Edit

Chemical Name:5-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pentanoic acid
CAS No.:123622-48-0
Molecular Formula:C20H21NO4
Molecular Weight:339.391
Hs Code.:29242990
European Community (EC) Number:832-970-3
Mol file:123622-48-0.mol

Synonyms:123622-48-0;Fmoc-5-Ava-OH;Fmoc-5-aminopentanoic acid;5-(Fmoc-amino)valeric acid;5-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pentanoic acid;5-(Fmoc-amino)pentanoic acid;Pentanoic acid, 5-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-;Fmoc-5-aminopentanoic acid, tech grade;5-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic Acid;MFCD00235889;Fmoc-5-Ava-OH Fmoc-5-aminopentanoic acid;N-(9-FLUORENYLMETHYLOXYCARBONYL)-5-AMINO-PENTANOIC ACID;5-({[(9H-FLUOREN-9-YL)METHOXY]CARBONYL}AMINO)PENTANOIC ACID;Fmoc-Ape(5)-OH;SCHEMBL97174;N-Fmoc-5-aminopentanoic acid;FMOC-5-AMINOPENTANOICACID;AC1980;AKOS013376082;CS-W009834;AS-70962;BP-28255;SY066349;Fmoc-5-Ava-OH, >=98.0% (HPLC);FT-0679730;EN300-81114;A890666;J-004964;N-(9-fluorenylmethoxycarbonyl)-5-amino-pentanoic acid;5-(((9H-fluoren-9-yl)methoxy)carbonylamino)pentanoic acid

Suppliers and Price of 5-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pentanoic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Fmoc-5-aminovaleric acid
2g
$ 333.00

Usbiological
Fmoc-5-aminopentanoic acid, tech grade
100mg
$ 305.00

TRC
Fmoc-5-aminopentanoicacid(TechnicalGrade)
500mg
$ 65.00

Sigma-Aldrich
Fmoc-5-Ava-OH ≥98.0% (HPLC)
1g
$ 48.30

Sigma-Aldrich
Fmoc-5-Ava-OH ≥98.0% (HPLC)
5g
$ 174.00

Matrix Scientific
Fmoc-5-aminopentanoic acid 95%
25g
$ 399.00

Matrix Scientific
Fmoc-5-aminopentanoic acid 95%
5g
$ 99.00

Iris Biotech GmbH
Fmoc-5-Ava-OH
5 g
$ 236.25

Iris Biotech GmbH
Fmoc-5-Ava-OH
1 g
$ 67.50

Frontier Specialty Chemicals
Fmoc-5-aminovalericacid 98%
5g
$ 339.00

Total 47 raw suppliers

Chemical Property of 5-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pentanoic acid Edit

Chemical Property:

Melting Point:135-136 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))
Boiling Point:562.24 °C at 760 mmHg
PKA:4.71±0.10(Predicted)
Flash Point:293.832 °C
PSA：75.63000
Density:1.231g/cm³
LogP:4.17090
Storage Temp.:2-8°C
XLogP3:3.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:339.14705815
Heavy Atom Count:25
Complexity:445

Purity/Quality:

98%,99%, ^*data from raw suppliers

Fmoc-5-aminovaleric acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCCCC(=O)O
Description Fmoc-5-aminopentanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Uses 5-(Fmoc-amino)valeric acid is used as pharmaceutical intermediate. Fmoc-5-aminopentanoic acid, tech grade

Technology Process of 5-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pentanoic acid

There total 5 articles about 5-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%