METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE

Base Information

• Chemical Name: METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE
• CAS No.: 882499-87-8
• Molecular Formula: C7H7BrN2O2
• Molecular Weight: 231.049
• Hs Code.: 2933399090
• Mol file: 882499-87-8.mol

Synonyms:2-Amino-5-bromoisonicotinicacid methyl ester;

Chemical Property of METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.000562mmHg at 25°C
• Refractive Index: 1.607
• Boiling Point: 311.5 °C at 760 mmHg
• PKA: 2.78±0.24(Predicted)
• Flash Point: 142.2 °C
• PSA: 65.21000
• Density: 1.662 g/cm³
• LogP: 1.79410
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-amino-5-bromoisonicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE

There total 1 articles about METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

methyl 2-aminoisonicotinate (6937-03-7) → methyl 2-amino-5-bromo-pyridine-4-carboxylate (882499-87-8)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

Reference yield: 55.8%

methyl 2-amino-5-bromo-pyridine-4-carboxylate (882499-87-8) + α-bromoacetophenone (70-11-1) → methyl 6-bromo-2-phenylimidazo[1,2-a]pyridine-7-carboxylate (1278407-60-5)

Guidance literature:

In ethanol; at 100 ℃; for 18h;

Reference yield:

methyl 2-amino-5-bromo-pyridine-4-carboxylate (882499-87-8) → ethyl 6'-{[(ethylamino)carbonyl]amino}-4'-(4-phenyl-1,3-thiazol-2-yl)-3,3'-bipyridine-5-carboxylate (1031432-52-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: chloroform / 3 h / 110 °C / Microwave irradiation

1.2: 20 °C

2.1: Lawessons reagent / tetrahydrofuran / 70 °C

3.1: acetonitrile / 16 h / 80 °C

4.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 100 °C / Microwave irradiation; Inert atmosphere

With Lawessons reagent; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; chloroform; water; acetonitrile;

upstream raw materials:

methyl 2-aminoisonicotinate

Downstream raw materials:

methyl 2-aminoisonicotinate

ethyl 6'-{[(ethylamino)carbonyl]amino}-4'-(4-phenyl-1,3-thiazol-2-yl)-3,3'-bipyridine-5-carboxylate

N-[5-bromo-4-(4-phenyl-1,3-thiazol-2-yl)pyridin-2-yl]-N'-ethylurea

6-(3-ethylureido)-4-(4-(trifluoromethyl)thiazol-2-yl)pyridin-3-ylboronic acid

Refernces

• 1、 -. "ORGANIC COMPOUNDS". Page/Page column 126-127. . Retrieved 2008/06/13.