1-(CHLORO-DIFLUORO-METHOXY)-4-NITRO-BENZENE

Base Information

• Chemical Name: 1-(CHLORO-DIFLUORO-METHOXY)-4-NITRO-BENZENE
• CAS No.: 40750-71-8
• Molecular Formula: C7H4ClF2NO3
• Molecular Weight: 223.563
• Hs Code.: 2909309090
• Mol file: 40750-71-8.mol

Synonyms:4-(Chlorodifluoromethoxy)-1-nitrobenzene;1-(Chloro-difluoro-methoxy)-4-nitro-benzene;Chloro(difluoro)methyl 4-nitrophenyl ether;

Chemical Property of 1-(CHLORO-DIFLUORO-METHOXY)-4-NITRO-BENZENE

Chemical Property:

• Vapor Pressure: 0.0152mmHg at 25°C
• Refractive Index: 1.516
• Boiling Point: 265.2 °C at 760 mmHg
• Flash Point: 114.2 °C
• PSA: 55.05000
• Density: 1.514 g/cm³
• LogP: 3.28590

Purity/Quality:

98%Min ^*data from raw suppliers

1-(Chlorodifluoromethoxy)-4-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(Chlorodifluoromethoxy)-4-nitrobenzene

Technology Process of 1-(CHLORO-DIFLUORO-METHOXY)-4-NITRO-BENZENE

There total 4 articles about 1-(CHLORO-DIFLUORO-METHOXY)-4-NITRO-BENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

difluorochloromethoxybenzene (770-11-6) → 1-(chlorodifluoromethoxy)-4-nitrobenzene (40750-71-8)

Guidance literature:

With sulfuric acid; nitric acid; In water; at 15 - 20 ℃;

Reference yield: 80.0%

4-nitrophenyl chlorothionoformate (1132-69-0) → 1-(chlorodifluoromethoxy)-4-nitrobenzene (40750-71-8)

Guidance literature:

With bromine trifluoride; In trichlorofluoromethane; at 0 ℃;

DOI:10.1002/ejoc.200800231

Reference yield:

(trichloromethoxy)benzene (34888-05-6) → 1-(chlorodifluoromethoxy)-4-nitrobenzene (40750-71-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen fluoride; perfluorooctyl sulfofluorure / 4 h / 5 - 110 °C / 18751.9 - 21002.1 Torr / Autoclave

2: sulfuric acid; nitric acid / water / 15 - 20 °C

With perfluorooctyl sulfofluorure; sulfuric acid; hydrogen fluoride; nitric acid; In water;

upstream raw materials:

4-nitrophenyl chlorothionoformate

(trichloromethoxy)benzene

difluorochloromethoxybenzene

Downstream raw materials:

4-[chloro(difluoro)methoxy]aniline

Refernces

• 1、 Hagooly, Youlia,Sasson, Revital,Welch, Michael J.,Rozen, Shlomo. "Preparation of alkyl and aryl chlorodifluoromethyl ethers using BrF 3". experimental part. p. 2875 - 2880. Retrieved 2009/04/07.