FMOC-(4-AMINOMETHYL)-CYCLOHEXANE CARBOXYLIC ACID

Base Information

• Chemical Name: FMOC-(4-AMINOMETHYL)-CYCLOHEXANE CARBOXYLIC ACID
• CAS No.: 188715-40-4
• Molecular Formula: C23H25 N O4
• Molecular Weight: 379.456
• Hs Code.: 2924299090
• Mol file: 188715-40-4.mol

Synonyms:TRANS-4-(9-FLUORENYLMETHYLOXYCARBONYLAMINOMETHYL)-CYCLOHEXANOIC ACID;FMOC-4-AMC-OH;FMOC-(4-AMINOMETHYL)-CYCLOHEXANE CARBOXYLIC ACID;FMOC-AMC-OH;4-[(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-METHYL]-CYCLOHEXANECARBOXYLIC ACID;TRANS-4-(9-FLUOROENYLMETHYLOXYCARBONYLAMINOMETHYL)-CYCLOHEXANOIC ACID;NALPHA-9-Fluorenylmethoxycarbonyl-4-(aminomethyl)-cyclohexanecarboxylic aci

Chemical Property of FMOC-(4-AMINOMETHYL)-CYCLOHEXANE CARBOXYLIC ACID

Chemical Property:

• Boiling Point: 604.9±28.0 °C(Predicted)
• PKA: 4.85±0.10(Predicted)
• PSA: 75.63000
• Density: 1.226±0.06 g/cm3(Predicted)
• LogP: 4.80700
• Storage Temp.: Store at 0-5°C

Purity/Quality:

99.3% ^*data from raw suppliers

Fmoc-4-aminomethylcyclohexane carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-(4-AMINOMETHYL)-CYCLOHEXANE CARBOXYLIC ACID

There total 2 articles about FMOC-(4-AMINOMETHYL)-CYCLOHEXANE CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-aminomethyl-cyclohexanecarboxylic acid (1197-17-7,1197-18-8,701-54-2) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → 4-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]cyclohexanecarboxylic acid (188715-40-4)

Guidance literature:

4-aminomethyl-cyclohexanecarboxylic acid; (fluorenylmethoxy)carbonyl chloride; With sodium carbonate; In 1,4-dioxane; water; at 20 ℃; for 2.5h;

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield:

4-aminomethyl-cyclohexanecarboxylic acid (1197-17-7,1197-18-8,701-54-2) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → 4-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]cyclohexanecarboxylic acid (188715-40-4)

Guidance literature:

4-aminomethyl-cyclohexanecarboxylic acid; N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; With sodium carbonate; In 1,4-dioxane; water;

With hydrogenchloride; In 1,4-dioxane; water; pH=3;

Reference yield: 98.0%

eicosanedioic acid mono(1,1-dimethylethyl)ester (683239-16-9) + C49H47N2O6Pol + Fmoc-Glu-OtBu (84793-07-7) + bromoacetic acid (79-08-3) + 4-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]cyclohexanecarboxylic acid (188715-40-4) + 8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid (166108-71-0,675606-79-8) → 20-[[4-[[(1S)-4-[2-[2-[2-[2-[2-[2-[[(1S)-5-[(2-bromoacetyl)amino]-1-carboxypentyl]amino]-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-1-carboxy-4-oxobutyl]carbamoyl]cyclohexyl]methylamino]-20-oxoicosanoic acid

Guidance literature:

C₄₉H₄₇N₂O₆Pol; With piperidine; In dichloromethane; N,N-dimethyl-formamide; wang resin

8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid; With N-[(6-chlorobenzotriazol-1-yl)oxy-(dimethylamino)methylene]-dimethyl-ammonium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; for 1h;

eicosanedioic acid mono(1,1-dimethylethyl)ester; Fmoc-Glu-OtBu; bromoacetic acid; 4-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]cyclohexanecarboxylic acid; 8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid; Further stages;

upstream raw materials:

4-aminomethyl-cyclohexanecarboxylic acid

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

(fluorenylmethoxy)carbonyl chloride

Refernces

• 1、 -. "Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders". Page/Page column 23. . Retrieved 2008/06/13.