Technology Process of (4S,4aR,5S,5aR,6R,12aS)-9-Amino-4-dimethylamino-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-8-phenyl-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide
There total 5 articles about (4S,4aR,5S,5aR,6R,12aS)-9-Amino-4-dimethylamino-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-8-phenyl-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide which
guide to synthetic route it.
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synthetic route:
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295356-13-7
(4S,4aR,5S,5aR,6R,12aS)-9-Amino-4-dimethylamino-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-8-phenyl-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide
- Guidance literature:
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With
copper(l) iodide; triphenyl-arsane;
bis-triphenylphosphine-palladium(II) chloride;
In
toluene;
for 6h;
Heating;
DOI:10.1016/S0040-4039(00)00768-1
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295356-13-7
(4S,4aR,5S,5aR,6R,12aS)-9-Amino-4-dimethylamino-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-8-phenyl-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide
- Guidance literature:
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Multi-step reaction with 5 steps
1.1: KNO3; H2SO4
2.1: H2 / Pd-C
3.1: n-BuONO / methanol; HCl
3.2: NaN3
4.1: 56 percent / HBr / acetic acid
5.1: 93 percent / AsPh3; CuI / Pd(PPh3)2Cl2 / toluene / 6 h / Heating
With
copper(l) iodide; n-Butyl nitrite; triphenyl-arsane; sulfuric acid; hydrogen bromide; hydrogen; potassium nitrate;
bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal;
In
hydrogenchloride; methanol; acetic acid; toluene;
1.1: Nitration / 2.1: Reduction / 3.1: Diazotization / 3.2: Substitution / 4.1: Reduction / 5.1: Substitution;
DOI:10.1016/S0040-4039(00)00768-1
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120793-45-5
<4S-(4α,12aα)>-4-(dimethylamino)-9-nitro-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
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295356-13-7
(4S,4aR,5S,5aR,6R,12aS)-9-Amino-4-dimethylamino-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-8-phenyl-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide
- Guidance literature:
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Multi-step reaction with 4 steps
1.1: H2 / Pd-C
2.1: n-BuONO / methanol; HCl
2.2: NaN3
3.1: 56 percent / HBr / acetic acid
4.1: 93 percent / AsPh3; CuI / Pd(PPh3)2Cl2 / toluene / 6 h / Heating
With
copper(l) iodide; n-Butyl nitrite; triphenyl-arsane; hydrogen bromide; hydrogen;
bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal;
In
hydrogenchloride; methanol; acetic acid; toluene;
1.1: Reduction / 2.1: Diazotization / 2.2: Substitution / 3.1: Reduction / 4.1: Substitution;
DOI:10.1016/S0040-4039(00)00768-1