11-BETA-HYDROXYANDROSTENEDIOL

Base Information

• Chemical Name: 11-BETA-HYDROXYANDROSTENEDIOL
• CAS No.: 3924-22-9
• Molecular Formula: C₁₉H₃₀O₃
• Molecular Weight: 306.445
• Mol file: 3924-22-9.mol

Synonyms:Androst-5-ene-3b,11b,17b-triol(7CI,8CI)

Chemical Property of 11-BETA-HYDROXYANDROSTENEDIOL

Chemical Property:

• PSA: 60.69000
• LogP: 2.64180

Purity/Quality:

99%, ^*data from raw suppliers

5-ANDROSTEN-3-BETA,11-BETA,17-BETA-TRIOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 11-BETA-HYDROXYANDROSTENEDIOL

There total 6 articles about 11-BETA-HYDROXYANDROSTENEDIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

11β-hydroxytestosterone (1816-85-9) → (3S,10R,11S,13S,14S,17R)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,11,17-triol (3924-22-9)

Guidance literature:

With sodium tetrahydroborate; acetic acid; In tetrahydrofuran; ethanol; for 8h; Cooling with ice;

Reference yield: 89.0%

3-acetoxyandrosta-3,5-diene-11,17-dione (17520-04-6) → (3S,10R,11S,13S,14S,17R)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,11,17-triol (3924-22-9)

Guidance literature:

With calcium borohydride; In ethanol; dichloromethane; 1) 12h, -15 deg C, 2) 6h, room temperature;

DOI:10.1016/S0040-4020(01)82010-X

Reference yield:

adrenosterone (382-45-6) → (3S,10R,11S,13S,14S,17R)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,11,17-triol (3924-22-9)

Guidance literature:

With calcium borohydride; Yield given. Multistep reaction; 2.) ethanol, -15 deg C;

DOI:10.1021/jo00262a013

upstream raw materials:

adrenosterone

3-acetoxyandrosta-3,5-diene-11,17-dione

11β-hydroxytestosterone

Downstream raw materials:

dehydro-oogoniol

dehydro-oogoniol

3β-Hydroxy-androsten-(5)-dion-(11,17)

Refernces

• 1、 Moon, Surksik,Tuhmiller, Louise M.,Hadha, Raj K.,McMorris, Trevor C.. "Synthesis of dehydro-oogoniol and oogoniol: The adrenosterone route". . p. 2287 - 2306. Retrieved 2007/10/02.