[7t,9c,11t,13c]retinoic acid methyl ester

Base Information

• Chemical Name: [7t,9c,11t,13c]retinoic acid methyl ester
• CAS No.: 68070-33-7
• Molecular Formula: C₂₁H₃₀O₂
• Molecular Weight: 314.468
• Mol file: 68070-33-7.mol

Synonyms:[7t,9c,11t,13c]retinoic acid methyl ester

Chemical Property of [7t,9c,11t,13c]retinoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [7t,9c,11t,13c]retinoic acid methyl ester

There total 21 articles about [7t,9c,11t,13c]retinoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 7,14-dihydroretinoate (140476-17-1) → retinoic acid methyl ester (339-16-2,16760-45-5,25428-67-5,58526-50-4,68070-31-5,68070-32-6,68070-33-7,71423-65-9,71423-66-0,74464-49-6,84415-26-9,98462-65-8)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; at 50 ℃; for 1.5h;

Reference yield: 78.0%

5,9-Bis-benzenesulfonyl-3,7-dimethylene-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nonanoic acid methyl ester (85329-46-0) → retinoic acid methyl ester (339-16-2,16760-45-5,25428-67-5,58526-50-4,68070-31-5,68070-32-6,68070-33-7,71423-65-9,71423-66-0,74464-49-6,84415-26-9,98462-65-8)

Guidance literature:

With sodium methylate; In methanol; for 7h; Heating;

DOI:10.1016/S0040-4039(00)85696-8

Reference yield: 25.0%

methyl 7,8-dihydroretinoate (51077-56-6) → retinoic acid methyl ester (339-16-2,16760-45-5,25428-67-5,58526-50-4,68070-31-5,68070-32-6,68070-33-7,71423-65-9,71423-66-0,74464-49-6,84415-26-9,98462-65-8)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; at 80 ℃; for 1.5h;

upstream raw materials:

5,9-Bis-benzenesulfonyl-3,7-dimethylene-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nonanoic acid methyl ester

methyl 7,8-dihydroretinoate

methyl 7,14-dihydroretinoate

(2E,6E)-9-Benzenesulfonyl-3,7-dimethyl-8-(tetrahydro-pyran-2-yloxy)-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,6-dienoic acid methyl ester

Downstream raw materials:

9-cis,13-cis-retinal

(9Z,13Z)-retinol

Refernces

• 1、 Curley, Robert W.,Fowble, John W.. "Assignment of 1H and 13C NMR Spectra of Retinoic Acid Ester Isomers Observed in the Long-Wavelength UV-Induced Photostationary State". . p. 707 - 709. Retrieved 2007/10/02.
• 2、 Mandai, T.,Iuchi, Y.,Suzuki, K.,Kawada, M.,Otera, J.. "NEW MASKED BUILDING BLOCK FOR ISOPRENOID POLYENE CHAIN SYNTHESIS". . p. 4721 - 4724. Retrieved 2007/10/02.