Carbobenzyloxy-L-alanyl-L-valine benzyl ester

Base Information

• Chemical Name: Carbobenzyloxy-L-alanyl-L-valine benzyl ester
• CAS No.: 66880-97-5
• Molecular Formula: C₂₃H₂₈N₂O₅
• Molecular Weight: 412.486
• European Community (EC) Number: 668-947-8
• Mol file: 66880-97-5.mol

Synonyms:CARBOBENZYLOXY-L-ALANYL-L-VALINE BENZYL ESTER;AKOS024432358

Chemical Property of Carbobenzyloxy-L-alanyl-L-valine benzyl ester

Chemical Property:

• XLogP3: 4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 11
• Exact Mass: 412.19982200
• Heavy Atom Count: 30
• Complexity: 554

Purity/Quality:

99% ^*data from raw suppliers

CARBOBENZYLOXY-L-ALANYL-L-VALINE BENZYL ESTER Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)C(C(=O)OCC1=CC=CC=C1)NC(=O)C(C)NC(=O)OCC2=CC=CC=C2

Technology Process of Carbobenzyloxy-L-alanyl-L-valine benzyl ester

There total 2 articles about Carbobenzyloxy-L-alanyl-L-valine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-valine benzyl ester (21760-98-5) + Z-Ala-O-COO-isoBu (25172-67-2) → Cbz-L-ala-L-val-Cbz (66880-97-5)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane; at -15 ℃; for 1h;

DOI:10.1039/b509920j

Reference yield:

N-Cbz-Ala (1142-20-7) → Cbz-L-ala-L-val-Cbz (66880-97-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / CH₂Cl₂ / 0.33 h / -15 °C

2: N-methylmorpholine / CH₂Cl₂ / 1 h / -15 °C

With 4-methyl-morpholine; In dichloromethane;

DOI:10.1039/b509920j

Reference yield:

Cbz-L-ala-L-val-Cbz (66880-97-5) → L-alanyl-L-valine (1472-66-8,1999-46-8,3303-45-5,3303-46-6,61427-69-8,99146-59-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 24h; under 4654.33 Torr;

DOI:10.1039/b509920j

upstream raw materials:

L-valine benzyl ester

Z-Ala-O-COO-isoBu

N-Cbz-Ala

Downstream raw materials:

L-alanyl-L-valine

Refernces