Dehydronaproxen

Base Information

• Chemical Name: Dehydronaproxen
• CAS No.: 27602-79-5
• Molecular Formula: C₁₄H₁₂O₃
• Molecular Weight: 228.247
• Mol file: 27602-79-5.mol

Synonyms:2-(6-methoxynaphth-2-yl)acrylic acid

Chemical Property of Dehydronaproxen

Chemical Property:

• Melting Point: 172-174 °C
• Boiling Point: 414.3±20.0 °C(Predicted)
• PKA: 3.70±0.11(Predicted)
• Density: 1.214±0.06 g/cm3(Predicted)

Purity/Quality:

99%min. ^*data from raw suppliers

Dehydronaproxen ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Dehydronaproxen is an analog of Naproxen (N377520), an anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory.

Technology Process of Dehydronaproxen

There total 22 articles about Dehydronaproxen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 2-(6-methoxynaphthalen-2-yl)acrylate (129113-02-6) → 2-(6-methoxynaphth-2-yl)acrylic acid (27602-79-5)

Guidance literature:

With potassium hydroxide; In acetone; for 16h; Ambient temperature;

DOI:10.1246/bcsj.63.640

Reference yield: 95.0%

carbon monoxide (201230-82-2) + 2-ethynyl-6-methoxynaphthalene (129113-00-4) → 2-(6-methoxynaphth-2-yl)acrylic acid (27602-79-5)

Guidance literature:

With water; palladium; In tetrahydrofuran; at 50 ℃; under 22501.8 Torr;

DOI:10.1016/0040-4039(95)01900-3

Reference yield: 95.0%

hydroxynaproxen → 2-(6-methoxynaphth-2-yl)acrylic acid (27602-79-5)

Guidance literature:

With acetic acid;

upstream raw materials:

methyl 2-(6-methoxynaphthalen-2-yl)acrylate

2-(6-methoxy-2-naphthyl)propenoic acid ethyl ester

carbon monoxide

2-ethynyl-6-methoxynaphthalene

Downstream raw materials:

naproxen

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

(R)-2-(6-methoxy-2-naphthyl)propionic acid

C₂₃H₂₁NO₄S

Refernces

• 1、 Chen, Pengquan,Cheng, Ruixiang,Jiang, Huanfeng,Lei, Ming,Lou, Hongming,Qi, Chaorong,Shi, Fuxing,Wang, Lu,Wu, Wanqing,Xiong, Wenfang,Zhu, Baiyao. "Palladium-Catalyzed Highly Regioselective Hydrocarboxylation of Alkynes with Carbon Dioxide". . p. 7968 - 7978. Retrieved 2020/08/21.
• 2、 Li, Jing,Shen, Jiefeng,Xia, Chao,Wang, Yanzhao,Liu, Delong,Zhang, Wanbin. "Asymmetric Hydrogenation of α-Substituted Acrylic Acids Catalyzed by a Ruthenocenyl Phosphino-oxazoline-Ruthenium Complex". supporting information. p. 2122 - 2125. Retrieved 2016/06/01.