Methyl 2,3-diaminobenzoate

Base Information

• Chemical Name: Methyl 2,3-diaminobenzoate
• CAS No.: 107582-20-7
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 2922499990
• Mol file: 107582-20-7.mol

Synonyms:2,3-Diaminobenzoicacid methyl ester;

Chemical Property of Methyl 2,3-diaminobenzoate

Chemical Property:

• Appearance/Colour: Yellow solid
• Vapor Pressure: 0.000277mmHg at 25°C
• Melting Point: 68-70 °C
• Refractive Index: 1.622
• Boiling Point: 322.596 °C at 760 mmHg
• PKA: 3.02±0.10(Predicted)
• Flash Point: 176.515 °C
• PSA: 78.34000
• Density: 1.26 g/cm³
• LogP: 1.80000
• Storage Temp.: -20°C Freezer

Purity/Quality:

99.0% ^*data from raw suppliers

Methyl 2,3-Diaminobenzoate >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38-43
• Safety Statements: 26-36/37/39-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2,3-diaminobenzoate

There total 24 articles about Methyl 2,3-diaminobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 3-nitroanthranilate (57113-91-4) → 2,3-diaminobenzoic acid methyl ester (107582-20-7)

Guidance literature:

With hydrogen; 20% Pd(OH)2 on carbon; In ethanol; at 20 ℃; for 48h; under 3040.2 Torr;

Reference yield: 98.0%

methyl ester of 2-amino-3-nitrobenzoic acid (57113-91-4) → 2,3-diaminobenzoic acid methyl ester (107582-20-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

Reference yield: 91.5%

methyl 3-azidoanthranilate → 2,3-diaminobenzoic acid methyl ester (107582-20-7)

Guidance literature:

With ammonium chloride; zinc; In water; acetonitrile; butan-1-ol; at 40 ℃; for 6h;

DOI:10.1021/acs.joc.1c00734

upstream raw materials:

methyl 3-nitroanthranilate

3-nitroanthranilic acid

2-acetylamino-3-nitro-benzoic acid methyl ester

methyl 2-(acetylamino)benzoate

Downstream raw materials:

2'-(2-benzyloxy-phenyl)-1H,1'H-[2,4']bibenzoimidazolyl-4-carboxylic acid methyl ester

2-amino-3-{[2-(2-benzyloxy-phenyl)-1H-benzoimidazole-4-carbonyl]-amino}-benzoic acid methyl ester

methyl 2-[2-(benzyloxy)phenyl]-1H-benzimidazole-4-carboxylate

2-[2-(benzyloxy)phenyl]-1H-benzimidazole-4-carboxylic acid

Refernces

• 1、 -. "MODIFIED PROTEINS AND PROTEIN DEGRADERS". Paragraph 00805-00807. . Retrieved 2021/12/08.
• 2、 -. "Method for Producing Alpha-Azidoaniline Derivative or Alpha,AlphaPrime-Diazide Derivative". . . Retrieved 2021/08/13.