2-Chloroethyl 4--1-piperazinecarboxylate

Base Information

• Chemical Name: 2-Chloroethyl 4--1-piperazinecarboxylate
• CAS No.: 120311-74-2
• Molecular Formula: C₂₀H₂₁ClF₂N₂O₂
• Molecular Weight: 394.849
• Mol file: 120311-74-2.mol

Synonyms:2-Chloroethyl 4--1-piperazinecarboxylate

Chemical Property of 2-Chloroethyl 4--1-piperazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Chloroethyl 4--1-piperazinecarboxylate

There total 1 articles about 2-Chloroethyl 4--1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

potassium carbonate (584-08-7) + 1,2-dichloro-ethane (107-06-2,52399-93-6) + 1-(4-fluorophenyl)methyl-piperazine (27469-60-9) → 2-Chloroethyl 4--1-piperazinecarboxylate (120311-74-2)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; In n-heptane; for 1.5h; Heating;

Reference yield: 86.0%

1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one (52099-72-6) + 2-Chloroethyl 4--1-piperazinecarboxylate (120311-74-2) → 2-(2,3-Dihydro-3-methylethenyl-2-oxo-1H-benzimidazol-1-yl)ethyl 4--1-piperazinecarboxylate (120311-79-7)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In acetonitrile; Heating;

Reference yield: 86.0%

2-Chloroethyl 4--1-piperazinecarboxylate (120311-74-2) + 6-Chloro-1,3-dihydro-1-(methylethenyl)-2H-benzimidazol-2-one (120311-75-3) → 2-(5-Chloro-2,3-dihydro-3-methylethenyl-2-oxo-1H-benzimidazol-1-yl)ethyl 4--1-piperazinecarboxylate (120311-87-7)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In acetonitrile; Heating;

upstream raw materials:

potassium carbonate

1,2-dichloro-ethane

1-(4-fluorophenyl)methyl-piperazine

Downstream raw materials:

2-(2,3-Dihydro-3-methylethenyl-2-oxo-1H-benzimidazol-1-yl)ethyl 4--1-piperazinecarboxylate

2-(5-Chloro-2,3-dihydro-3-methylethenyl-2-oxo-1H-benzimidazol-1-yl)ethyl 4--1-piperazinecarboxylate

2-(2,3-Dihydro-5-methyl-3-methylethenyl-2-oxo-1H-benzimidazol-1-yl)ethyl 4--1-piperazinecarboxylate

2-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)ethyl 4--1-piperazinecarboxylate

Refernces