4,4-DIMETHYLCYCLOHEXYLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: 4,4-DIMETHYLCYCLOHEXYLAMINE HYDROCHLORIDE
• CAS No.: 25834-99-5
• Molecular Formula: C8H18ClN
• Molecular Weight: 163.691
• Hs Code.: 2921300090
• Mol file: 25834-99-5.mol

Synonyms:Cyclohexanamine,4,4-dimethyl-, hydrochloride (9CI);Cyclohexylamine, 4,4-dimethyl-,hydrochloride (8CI);(4,4-Dimethylcyclohexyl)amine hydrochloride;4,4-Dimethylcyclohexanamine hydrochloride;

Chemical Property of 4,4-DIMETHYLCYCLOHEXYLAMINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 2.38mmHg at 25°C
• Melting Point: 280 °C
• Refractive Index: 1.444
• Boiling Point: 162 °C at 760 mmHg
• Flash Point: 42.2 °C
• PSA: 26.02000
• Density: 0.834g/cm³
• LogP: 3.41620
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4,4-Dimethylcyclohexanamine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4-DIMETHYLCYCLOHEXYLAMINE HYDROCHLORIDE

There total 5 articles about 4,4-DIMETHYLCYCLOHEXYLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4,4-dimethylcyclohexan-1-one oxime (4701-96-6) → CR 2863 hydrochloride (25834-99-5)

Guidance literature:

4,4-dimethylcyclohexanone oxime; With hydrogen; Raney 2800 nickel; In ethanol; water; under 2585.81 Torr;

With hydrogenchloride; In ethyl acetate;

Reference yield:

4,4-dimethylcyclohexan-1-one oxime (4701-96-6) + nickel (7440-02-0) → CR 2863 hydrochloride (25834-99-5)

Guidance literature:

With hydrogenchloride; In diethyl ether; ethanol; water;

Reference yield:

4,4-dimethylcyclohexenone (1073-13-8) → CR 2863 hydrochloride (25834-99-5)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium-carbon / ethyl acetate

2: hydroxylamine hydrochloride; sodium carbonate / ethanol; water

3: hydrogenchloride / diethyl ether; ethanol; water

With hydrogenchloride; hydroxylamine hydrochloride; sodium carbonate; palladium-carbon; In diethyl ether; ethanol; water; ethyl acetate;

upstream raw materials:

4,4-dimethylcyclohexan-1-one oxime

nickel

4,4-dimethylcyclohexenone

4,4-dimethylcyclohexane-1-one

Downstream raw materials:

1,1-dimethylethyl({4-[(4-amino-3-nitrophenyl)oxy]phenyl}methyl)(4,4-dimethylcyclohexyl)carbamate

3′-({2-[(4,4-dimethylcyclohexyl)amino]ethyl}oxy)-4-biphenylcarboxamide hydrochloride

(4,4-dimethylcyclohexyl)({3-[1-(triphenylmethyl)-1H-benzimidazol-5-yl]phenyl}methyl)amine

(4,4-dimethylcyclohexyl)({3-[1-(triphenylmethyl)-1H-benzimidazol-6-yl]phenyl}methyl)amine

Refernces

• 1、 Wang, Jun,Ma, Chunlong,Wu, Yibing,Lamb, Robert A.,Pinto, Lawrence H.,Degrado, William F.. "Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel". supporting information; experimental part. p. 13844 - 13847. Retrieved 2011/10/31.
• 2、 -. "METHOD OF TREATMENT USING NOVEL ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS". . . Retrieved 2010/05/13.