L-Histidine hydrochloride hydrate

Base Information

• Chemical Name: L-Histidine hydrochloride hydrate
• CAS No.: 5934-29-2
• Molecular Formula: C6H12ClN3O3
• Molecular Weight: 209.633
• Hs Code.: HISTIDINE HCl, MONOHYDRATE PRODUCT IDENTIFICATION
• European Community (EC) Number: 611-821-4
• UNII: X573657P6P
• DSSTox Substance ID: DTXSID00208089
• NCI Thesaurus Code: C87334
• RXCUI: 1305609
• Mol file: 5934-29-2.mol

Synonyms:5934-29-2;L-Histidine Hydrochloride Monohydrate;L-Histidine hydrochloride hydrate;L-Histidine monohydrochloride monohydrate;(S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid hydrochloride hydrate;L-Histidine HCl hydrate;L-Histidine, monohydrochloride, monohydrate;7048-02-4;H-His-OH.HCl.H2O;histidine hydrochloride monohydrate;Histidine monohydrochloride monohydrate;L-Histidine, hydrochloride, monohydrate;Histidine hydrochloride hydrate;UNII-X573657P6P;Histidine, monohydrochloride, monohydrate, L-;L-Histidine (hydrochloride hydrate);MFCD00151027;X573657P6P;(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid hydrate hydrochloride;(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid;hydrate;hydrochloride;C6H9N3O2.xClH;Histidine, hydrochloride, L-;Histidine Hydrochloride Monohydrate (L-Histidine Hydrochloride Monohydrate);C6-H9-N3-O2.x-Cl-H;Histidine, monohydrochloride, monohydrate;SCHEMBL50270;C6H9N3O2.ClH.H2O;DTXSID00208089;s3096;(2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid hydrate hydrochloride;AKOS015855386;AKOS015919710;C6-H9-N3-O2.Cl-H.H2-O;CS-W015139;HY-W014423;L-Histidine monohydrochloride monohydrat;AS-64939;L-Histidine hydrochloride hydrate (JP17);LS-75854;L-HISTIDINE MONOHYDROCHLORIDE [FCC];L-Histidine,hydrochloride,hydrate(1:?:1);Histidine, hydrochloride, hydrate (1:1:1);L-Histidine,hydrochloride, hydrate (1:?:1);D02072;D86696;D94452;H-2311;L-HISTIDINE HYDROCHLORIDE HYDRATE [JAN];HISTIDINE, L-, HYDROCHLORIDE MONOHYDRATE;A832275;HISTIDINE, L-, MONOHYDROCHLORIDE MONOHYDRATE;HISTIDINE MONOHYDROCHLORIDE MONOHYDRATE, (-)-;L-HISTIDINE, HYDROCHLORIDE, HYDRATE (1:1:1);Q27293570;HISTIDINE HYDROCHLORIDE MONOHYDRATE [EP MONOGRAPH];L-Histidine monohydrochloride monohydrate, p.a., 98.5%;L-HISTIDINE MONOHYDROCHLORIDE MONOHYDRATE [USP-RS];L-Histidine monohydrochloride monohydrate, >=98% (HPLC);L-Histidine monohydrochloride monohydrate, >=99.0% (AT);(S)-2-Amino-3-(1H-imidazol-4-yl)propanoicacidhydrochloride hydrate;L-Histidine hydrochloride monohydrate;L-Histidine HCl monohydrate;(2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid;L-Histidine monohydrochloride monohydrate, SAJ special grade, >=99.0%;L-Histidine monohydrochloride monohydrate, Vetec(TM) reagent grade, 99%;Histidine hydrochloride monohydrate, European Pharmacopoeia (EP) Reference Standard;L-Histidine monohydrochloride monohydrate, Cell Culture Reagent (H-L-His-OH.HCl.H2O);L-Histidine monohydrochloride monohydrate, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%;L-Histidine monohydrochloride monohydrate, United States Pharmacopeia (USP) Reference Standard

Chemical Property of L-Histidine hydrochloride hydrate

Chemical Property:

• Appearance/Colour: white crystals or cryst, or granular powder
• Vapor Pressure: 3.25E-09mmHg at 25°C
• Melting Point: 254 °C (dec.)(lit.)
• Boiling Point: 458.9 °C at 760 mmHg
• Flash Point: 231.3 °C
• PSA: 101.23000
• Density: 1.485 g/cm3
• LogP: 0.80210
• Storage Temp.: Store at RT.
• Solubility.: H2O: 100 mg/mL
• Water Solubility.: 169.9 g/L (20 ºC)
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 209.0567189
• Heavy Atom Count: 13
• Complexity: 151

Purity/Quality:

99.8% ^*data from raw suppliers

L-Histidine Hydrochloride Hydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 22-24/25-36/37-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Biological Agents -> Amino Acids and Derivatives
• Canonical SMILES: C1=C(NC=N1)CC(C(=O)O)N.O.Cl
• Isomeric SMILES: C1=C(NC=N1)C[C@@H](C(=O)O)N.O.Cl
• Uses: L-Histidine is used in cell culture media formulations used in biomanufacturing. L-Histidine has been used to study cultures of the human T-lymphoblastic leukemia cell line MOLT-4 to study modulation of apoptosis. L-Histidine monohydrochloride, non-animal, is used in cell culture media formulations used in biomanufacturing. The use of non-animal-sourced L-Histidine and other components avoids the risk of contaminating bioproducts with adventitious viruses. L-Histidine Hydrochloride Monohydrate can be used as AhR activators to treat gluten-induced gastrointestinal diseases. It can also be used for hair coloring method.

Technology Process of L-Histidine hydrochloride hydrate

There total 2 articles about L-Histidine hydrochloride hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-histidine (71-00-1) → L-histidine hydrochloride monohydrate (5934-29-2)

Guidance literature:

With hydrogenchloride; water; at 26.84 ℃;

DOI:10.1016/j.saa.2013.11.021

Reference yield:

→ L-histidine hydrochloride monohydrate (5934-29-2)

Guidance literature:

Trennung von D,L-His*HCl: Zugabe von DL-His*HCl*H2O oder aktiv.Form in wss. D,L-His*HCl;

Reference yield: 66.0%

4-methoxybenzyloxycarbonyl azide (25474-85-5) + L-histidine hydrochloride monohydrate (5934-29-2) → (S)-3-(1H-Imidazol-4-yl)-2-(4-methoxy-benzyloxycarbonylamino)-propionic acid; hydrate

Guidance literature:

DOI:10.1248/cpb.37.3112

upstream raw materials:

L-histidine

Downstream raw materials:

N-(tert-butoxycarbonyl)-L-histidine

N-[(benzyloxy)carbonyl]-L-histidine

N-benzoyl-L-histidine

Cu(OCOCH(NH₂)CH₂(C₃H₃N₂))2

Refernces

• 1、 -. "Safe and Effective Method of Treating Ulcerative Colitis with Anti-IL12/IL23 Antibody". . . Retrieved 2020/04/10.