(S)-(+)-2-Chloropropan-1-ol

Base Information

• Chemical Name: (S)-(+)-2-Chloropropan-1-ol
• CAS No.: 19210-21-0
• Molecular Formula: C3H7ClO
• Molecular Weight: 94.541
• Hs Code.: 29055998
• Mol file: 19210-21-0.mol

Synonyms:1-Propanol,2-chloro-, (S)-;1-Propanol, 2-chloro-, (S)-(+)- (8CI);(S)-2-Chloro-1-propanol;S-(+)-2-Chloro-1-propanol;

Chemical Property of (S)-(+)-2-Chloropropan-1-ol

Chemical Property:

• Appearance/Colour: clear colourless to slightly yellow liquid
• Vapor Pressure: 3.68mmHg at 25°C
• Refractive Index: n20/D 1.438(lit.)
• Boiling Point: 130 °C
• PKA: 14.16±0.10(Predicted)
• Flash Point: 51 °C
• PSA: 20.23000
• Density: 1.09 g/cm³
• LogP: 0.60600
• Storage Temp.: Flammables area
• Water Solubility.: soluble

Purity/Quality:

98%,99%, ^*data from raw suppliers

(S)-(+)-2-Chloro-1-propanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 10-20/21/22-36-36/37/38
• Safety Statements: 16-26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Chloro-1-propanol can be used to treat cardiovascular diseases.

Technology Process of (S)-(+)-2-Chloropropan-1-ol

There total 2 articles about (S)-(+)-2-Chloropropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-2-Chloro-propionic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester (104897-94-1) → (S)-2-chloropropan-1-ol (19210-21-0) + (-)-10-dicyclohexylsulfamoyl-D-isoborneol (96303-88-7)

Guidance literature:

With calcium borohydride; In tetrahydrofuran;

Reference yield:

propene (187737-37-7,13987-01-4,15220-87-8,9003-07-0,676-63-1,25085-53-4) → (S)-2-chloropropan-1-ol (19210-21-0) + 1-chloro-2(S)-hydroxypropane (37493-16-6) + (R)-(-)-1-chloro-2-propanol (19141-39-0) + (R)-(-)-2-chloro-propan-1-ol (37493-14-4)

Guidance literature:

With copper dichloride; [Pd(CH₃CN)2{(S)-BINAP}](BF₄)2; 1,3-diacetyl acetone; In tetrahydrofuran; at 25 ℃; Further Variations:; Catalysts; Solvents; Reagents; Product distribution;

DOI:10.1016/S0022-328X(00)00070-X

Reference yield: 83.0%

trans-bis(benzonitrile)dichloroplatinum(II) (14873-63-3,15617-19-3,51921-56-3) + (S)-2-chloropropan-1-ol (19210-21-0) → trans-[PtCl2[(R)-N=C(C6H5)OCH2CH(CH3)]2]

Guidance literature:

With n-BuLi; In tetrahydrofuran; hexane; under N2, alcohol soln. in THF treated with n-BuLi (hexane) at 0°C, platinum complex added, react. mixt stirred for 1 h at 0°C and 1 h at room temp., evapd.; residue dissolved in CH2Cl2, treated with activated charcoal, filtered,concd., pptd. with Et2O, filtered off, dried in vac., elem. anal.;

DOI:10.1016/S0020-1693(99)00615-5

upstream raw materials:

(S)-2-Chloro-propionic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

propene

Downstream raw materials:

(S)-1,2-dichloropropane

(R)-4-methyl-1,3-dioxolane

(R)-propylene oxide

(S)-Propylene oxide

Refernces

• 1、 Oppolzer, Wolfgang,Dudfield, Philip. "ASYMMETRIC HALOGENATION OF CAMPHOR-10-SULFONIC ACID DERIVED ESTERS: AN EFFICIENT NEW ROUTE TO ENANTIOMERICALLY PURE HALOHYDRINS AND EPOXIDES.". . p. 5037 - 5040. Retrieved 2007/10/02.