2,5-Dimethoxybenzenesulfonamide

Base Information

• Chemical Name: 2,5-Dimethoxybenzenesulfonamide
• CAS No.: 19116-90-6
• Molecular Formula: C8H11NO4S
• Molecular Weight: 217.246
• Hs Code.: 2935009090
• DSSTox Substance ID: DTXSID20172637
• Nikkaji Number: J3.307.123J
• Wikidata: Q83042734
• ChEMBL ID: CHEMBL1547606
• Mol file: 19116-90-6.mol

Synonyms:2,5-Dimethoxybenzenesulfonamide;19116-90-6;2,5-dimethoxybenzenesulphonamide;2,5-dimethoxybenzene-1-sulfonamide;Benzenesulfonamide, 2,5-dimethoxy-;BRN 2648546;AI3-17891;3-11-00-00570 (Beilstein Handbook Reference);Benzenesulfonamide,2,5-dimethoxy-;BSA-1;MLS000064507;2,5-dimethoxyphenylsulfonamide;SCHEMBL1137736;CHEMBL1547606;DTXSID20172637;HMS1594F02;HMS2431H12;BBL100205;GS0442;MFCD00833415;STL553771;AKOS000139130;PS-3154;SB79024;LS-31517;SMR000077039;CS-0308864;FT-0610400;EN300-13704;A813473;Z45415657

Chemical Property of 2,5-Dimethoxybenzenesulfonamide

Chemical Property:

• Vapor Pressure: 3.9E-07mmHg at 25°C
• Melting Point: 150 °C
• Refractive Index: 1.536
• Boiling Point: 416.2 °C at 760 mmHg
• Flash Point: 205.5 °C
• PSA: 87.00000
• Density: 1.305 g/cm³
• LogP: 2.13230
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 217.04087901
• Heavy Atom Count: 14
• Complexity: 272

Purity/Quality:

98%min ^*data from raw suppliers

2,5-Dimethoxybenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)OC)S(=O)(=O)N

Technology Process of 2,5-Dimethoxybenzenesulfonamide

There total 2 articles about 2,5-Dimethoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-dimethoxybenzene-1-sulfonyl chloride (1483-28-9) → 2,5-dimethoxy-benzenesulfonic acid amide (19116-90-6)

Guidance literature:

With ammonium hydroxide;

DOI:10.1039/j39690001341

Reference yield:

1,4-dimethoxybezene (150-78-7) → 2,5-dimethoxy-benzenesulfonic acid amide (19116-90-6)

Guidance literature:

With chlorosulphuric acid; chloroform; und Eindampfen des Reaktionsgemisches mit Ammoniumcarbonat;

DOI:10.1021/ja01860a049

Reference yield: 92.0%

2,5-dimethoxy-benzenesulfonic acid amide (19116-90-6) + acetic anhydride (108-24-7) → N-((2,5-dimethoxyphenyl)sulfonyl)acetamide (28011-66-7)

Guidance literature:

With zinc(II) chloride; at 20 ℃;

DOI:10.1039/c8cc08837c

upstream raw materials:

1,4-dimethoxybezene

2,5-dimethoxybenzene-1-sulfonyl chloride

Downstream raw materials:

2-Cyclopentyl-N-{1-[4-(2,5-dimethoxy-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1H-indol-6-yl}-acetamide

N-[2-(1H-Indol-4-yloxy)-acetyl]-2,5-dimethoxy-benzenesulfonamide

N-((2,5-dimethoxyphenyl)sulfonyl)acetamide

Refernces

• 1、 -. "Herbicidal aryl triazolinones". . . Retrieved 2008/06/13.