Tetrazolium blue

Base Information

• Chemical Name: Tetrazolium blue
• CAS No.: 1871-22-3
• Deprecated CAS: 101329-54-8,106395-82-8,1184-30-1,146671-23-0,3633-57-6,42988-44-3,412909-24-1,562102-26-5,679787-06-5
• Molecular Formula: C40H32Cl2N8O2
• Molecular Weight: 727.652
• Hs Code.: 29339990
• European Community (EC) Number: 217-488-8
• UNII: 0468TBH014
• DSSTox Substance ID: DTXSID70889369
• Wikidata: Q27145163
• ChEMBL ID: CHEMBL404862
• Mol file: 1871-22-3.mol

Synonyms:4-anisyltetrazolium blue;p-anisyltetrazolium blue;Tetrazolium blue

Chemical Property of Tetrazolium blue

Chemical Property:

• Appearance/Colour: yellow crystalline solid
• Melting Point: 255 °C (dec.)(lit.)
• Refractive Index: 1.6000 (estimate)
• PSA: 87.64000
• Density: 1.9137 (rough estimate)
• LogP: 0.42760
• Storage Temp.: -20°C
• Solubility.: Soluble in water;freely soluble ethanol, methanol, chloroform; i
• Water Solubility.: Soluble in hot water (5 mg/ml), methanol (50 mg/ml), ethanol, and chloroform. Insoluble in acetone.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 9
• Exact Mass: 726.2025277
• Heavy Atom Count: 52
• Complexity: 951

Purity/Quality:

98.0% ^*data from raw suppliers

Tetrazolium blue chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T, Xi
• Hazard Codes: T,Xi
• Statements: 45-36/37/38
• Safety Statements: 53-45-36-26-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)C2=CC(=C(C=C2)N3N=C(N=[N+]3C4=CC=CC=C4)C5=CC=CC=C5)OC)N6N=C(N=[N+]6C7=CC=CC=C7)C8=CC=CC=C8.[Cl-].[Cl-]
• Uses: For research in seed germination, as stain for bacteria and molds, in histochemical studies, to demonstrate oxidation-reduction enzymes in normal and cancerous tissues. See also Triphenyltetrazolium Chloride. Tetrazolium Blue Chloride is used for its anti-plasmodium activity. Also used in the study of inhibition of diphenyltetrazolium bromide (MTT) reduction by β-amyloid peptides resulting in neurodegenerative manifestations. Dyes and metabolites.

Technology Process of Tetrazolium blue

There total 2 articles about Tetrazolium blue which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isopentyl nitrite (110-46-3) → tetrazolium blue (1871-22-3)

Guidance literature:

With hydrogenchloride; chloroform;

Reference yield:

→ tetrazolium blue (1871-22-3)

Guidance literature:

With lead(II,IV) oxide; lead acetate; acetic acid;

Reference yield:

cobalt(II) sulphate heptahydrate + tetrazolium blue (1871-22-3) + 4-(2-pyridylazo) resorcinol → 3,3'-(3,3'-dimethoxy-4,4'-biphenylene)bis(2,5-diphenyl-2H-tetrazolium)[Co(II)(4-(2-pyridylazo)resorcinolate)2]

Guidance literature:

In chloroform;

DOI:10.2298/JSC140514102V

upstream raw materials:

isopentyl nitrite