Cefaloject

Base Information

• Chemical Name: Cefaloject
• CAS No.: 24356-60-3
• Molecular Formula: C₁₇H₁₆N₃O₆S₂*Na
• Molecular Weight: 445.452
• Hs Code.: 2941906000
• NSC Number: 179171
• Mol file: 24356-60-3.mol

Synonyms:BL P 1322;BL-P 1322;BLP 1322;Brisfirina;Céfaloject;Cefadyl;Cefapirin;Cephapirin;Cephapirin Monosodium Salt;Cephapirin Sodium;Cephapirin, Sodium;Monosodium Salt, Cephapirin;Salt, Cephapirin Monosodium;Sodium Cephapirin

Chemical Property of Cefaloject

Chemical Property:

• Vapor Pressure: 6.98E-26mmHg at 25°C
• Boiling Point: 783.9 °C at 760 mmHg
• PKA: pKa 2.15 (Uncertain)
• Flash Point: 427.9 °C
• PSA: 179.33000
• LogP: -0.53050
• Storage Temp.: 0-6°C
• Solubility.: Soluble in water, practically insoluble in methylene chloride.
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 8
• Exact Mass: 446.04564690
• Heavy Atom Count: 29
• Complexity: 707

Purity/Quality:

99% ^*data from raw suppliers

Cephapirin sodium ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-42/43
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OCC1=C(N2C(C(C2=O)NC(=O)CSC3=CC=NC=C3)SC1)C(=O)O.[Na+]
• Description: Cephapirin sodium (Cefapirin sodium), a semisynthetic cephalosporin antibiotic, is bactericidal against strains of gram-positive and gram-negative bacteria.Cephapirin is closely resembles cephalothin in chemical and pharmacokinetic properties. Cephapirin, have cephalosporanic acid core with the acetyloxymethyl group at the 3rd position and having IUPAC name (6R,7R)-3-(Acetoxymethy)-8- oxo-7-{[(pyridin-4-ylsulfanyl)acetyl]amino}-5-thia- 1-azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid. It is unstable in acid and must be administered parenteral. It has similar mechanism as other cephalosporins. It is marketed under the trade name Cefadyl. It is effective against a wide variety of gram-positive and gramnegative bacteria; used as the sodium salt. Among the most serious adverse reactions of cefapirin, that is， neutropenia, leukopenia, anemia, bone marrowdepression, and allergic reactions, it has been discontinued in the United States (Wiesner, 1972).
• Uses: Cefapirin sodium is very similar to cephalothin (Bran et al., 1972). Cephapirin is now used almost exclusively in veterinary practice.
• Therapeutic Function: Antibacterial

Technology Process of Cefaloject

There total 1 articles about Cefaloject which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cephapirin (21593-23-7) → cephapirin Sodium (24356-60-3,54600-91-8)

Guidance literature:

With sodium isooctanoate; In dichloromethane; dimethyl sulfoxide; at 0 - 20 ℃; for 1.33333h; Temperature;

upstream raw materials:

cephapirin

Refernces