Technology Process of (Z/E)-3-(2-bromo-6-methoxyphenyl)-2-(2-carboxy-4,5-methylenedioxyphenyl)acrylic acid methyl ester
There total 9 articles about (Z/E)-3-(2-bromo-6-methoxyphenyl)-2-(2-carboxy-4,5-methylenedioxyphenyl)acrylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-methoxycarbonyl-4,5-methylenedioxyphenyl acetic acid methyl ester; 2-bromo-6-methoxybenzaldehyde;
With
methanol; sodium methylate;
for 4h;
Reflux;
With
hydrogenchloride;
In
water;
at 0 ℃;
DOI:10.1039/c0ob01214a
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: piperidine; pyridine
2.1: 10% palladium on activated charcoal; hydrogen
3.1: oxalyl dichloride / dichloromethane
4.1: tin(IV) chloride
5.1: hydrogenchloride; n-Amyl nitrite / methanol; water
6.1: p-toluenesulfonyl chloride; sodium hydroxide / water
7.1: dichloromethane / 0 °C
8.1: methanol; sodium methylate / 4 h / Reflux
8.2: 0 °C
With
piperidine; pyridine; hydrogenchloride; methanol; oxalyl dichloride; n-Amyl nitrite; 10% palladium on activated charcoal; hydrogen; sodium methylate; tin(IV) chloride; p-toluenesulfonyl chloride; sodium hydroxide;
In
methanol; dichloromethane; water;
4.1: Friedel-Crafts acylation;
DOI:10.1039/c0ob01214a
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tin(IV) chloride
2.1: hydrogenchloride; n-Amyl nitrite / methanol; water
3.1: p-toluenesulfonyl chloride; sodium hydroxide / water
4.1: dichloromethane / 0 °C
5.1: methanol; sodium methylate / 4 h / Reflux
5.2: 0 °C
With
hydrogenchloride; methanol; n-Amyl nitrite; sodium methylate; tin(IV) chloride; p-toluenesulfonyl chloride; sodium hydroxide;
In
methanol; dichloromethane; water;
1.1: Friedel-Crafts acylation;
DOI:10.1039/c0ob01214a
