2,2'-(2-(p-tolyl)propane-1,3-diyl)diquinoline

Base Information

• Chemical Name: 2,2'-(2-(p-tolyl)propane-1,3-diyl)diquinoline
• CAS No.: 103280-96-2
• Molecular Formula: C₂₈H₂₄N₂
• Molecular Weight: 388.512
• Mol file: 103280-96-2.mol

Synonyms:2,2'-(2-(p-tolyl)propane-1,3-diyl)diquinoline

Chemical Property of 2,2'-(2-(p-tolyl)propane-1,3-diyl)diquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2'-(2-(p-tolyl)propane-1,3-diyl)diquinoline

There total 4 articles about 2,2'-(2-(p-tolyl)propane-1,3-diyl)diquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-methylquinoline (91-63-4) + 4-methyl-benzaldehyde (104-87-0) → 2,2'-(2-(p-tolyl)propane-1,3-diyl)diquinoline (103280-96-2)

Guidance literature:

With tert-butylammonium hexafluorophosphate(V); calcium(II) trifluoromethanesulfonate; In acetonitrile; at 100 ℃; for 12h; Reflux; Green chemistry;

DOI:10.1016/j.tetlet.2015.09.035

Reference yield:

2-methylquinoline (91-63-4) → 2,2'-(2-(p-tolyl)propane-1,3-diyl)diquinoline (103280-96-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid anhydride / 125 °C

2: H₂SO₄

With sulfuric acid; acetic anhydride;

DOI:10.1039/jr9590001641

Reference yield:

4-methyl-benzaldehyde (104-87-0) → 2,2'-(2-(p-tolyl)propane-1,3-diyl)diquinoline (103280-96-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid anhydride / 125 °C

2: H₂SO₄

With sulfuric acid; acetic anhydride;

DOI:10.1039/jr9590001641

upstream raw materials:

2-[(1E)-2-(4-methylphenyl)ethenyl]quinoline

2-methylquinoline

4-methyl-benzaldehyde

Refernces

• 1、 Jin, Jia-Jia,Wang, Dong-Chao,Niu, Hong-Ying,Wu, Shan,Qu, Gui-Rong,Zhang, Zhong-Bo,Guo, Hai-Ming. "Br?nsted acid catalyzed synthesis of 1,3-di(2-quinolyl)propane derivatives via tandem C(sp3)-H functionalization". . p. 6579 - 6584. Retrieved 2013/07/25.