Technology Process of Alverine citrate
There total 5 articles about Alverine citrate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
ethyl acetate; isopropyl alcohol;
at 45 - 50 ℃;
Solvent;
Temperature;
- Guidance literature:
-
1-Bromo-3-phenylpropane; ethanamine hydrochloride;
With
tetrabutylammomium bromide; sodium hydroxide;
at 85 - 90 ℃;
citric acid;
In
ethanol;
at 15 ℃;
for 6h;
Temperature;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 0 - 30 °C
2: sodium bromide / N,N-dimethyl-formamide / 25 - 30 °C
3: N-benzyl-N,N,N-triethylammonium chloride; triethylamine / N,N-dimethyl-formamide; water / 10 - 40 °C
4: ethyl acetate; isopropyl alcohol / 45 - 50 °C
With
N-benzyl-N,N,N-triethylammonium chloride; triethylamine; sodium bromide;
In
dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
